教師簡介

代表著作

    期刊論文(2011-present)

  • Lu T-L and Chen C-M*. (2015) ß-Catenin in epithelial tumorigenesis. Aging 7: 467-468. * corresponding author.
  • Liang, C.-C., Lu, T.-L., Yu, Y.-R., You, L.-R. and Chen, C.-M.* (2015) β-catenin activation drives thymoma initiation and progression in mice. Oncotarget. 6(16):13978-13993. * corresponding author.
  • Lu, T.-L. and Chen, C.-M.* (2015) Differential requirements for beta-catenin in murine prostate cancer originating from basal versus luminal cells. J Pathol. 236, 290-301. * corresponding author.
  • Ke, C.-Y., Xiao, W.-L., Chen, C.-M., Lo, L.-J., and Wong, F.-H.*. (2015) IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion. Sci Rep 5, 12791.
  • Liang, C.-C., You, L.-R., Yen, J.J.-Y., Liao, N.-S. Yang-Yen, H.-F. and Chen, C.-M.* (2013) Thymic epithelial beta-catenin is required for thymic homeostasis and function. Immunol Cell Biol, 91, 511-523. * corresponding author.
  • Lu, T.-L., Huang, Y.-F., You, L.-R., Chao, N.-C., Su, F.-Y., Chang, J.-L., and Chen, C.-M.* (2013). Conditionally Ablated Pten in Prostate Basal Cells Promotes Basal-to-Luminal Differentiation and Causes Invasive Prostate Cancer in Mice. Am J Pathol. 182, 975-991. * corresponding author.
  • Chiang M-F, Yang S-Y, Lin I-Y, Hong J-B, Lin S-J, Ying H-Y, Chen C-M, Wu S-Y, Liu F-T, Lin K-I* (2013) Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice, Proc Natl Acad Sci USA. 110, 6476-6481.
  • Hsu, W.H., Yu, Y.R., Hsu, S.H., Yu, W.C., Chu, Y.H., Chen, Y.J., Chen, C.M., and You, L.R.* (2013). The Wilms' tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium. Exp Cell Res. 319, 1365-1381.
  • Cheng TL, Wu YT, Lai CH, Kao YC, Kuo CH, Liu SL, Hsu YY, Chen PK, Cho CF, Wang KC, Lin WL, Chang BI, Chen CM, Weiler H, Shi GY, Wu HL* (2013) Thrombomodulin Regulates Keratinocyte Differentiation and Promotes Wound Healing, J Invest Dermatol. 133, 1638-1645.
  • Chun-Ming Chen, Tsai-Ling Lu, Fang-Yi Su and Li-Ru You (2012). Susceptibility of Epithelium to PTEN-Deficient Tumorigenesis, Tumor Suppressor Genes, Yue Cheng (Ed.), ISBN: 978-953-307-879-3, InTech, Available from: http://www.intechopen.com/articles/show/title/susceptibility-of-epithelium-to-pten-deficient-tumorigenesis * corresponding author.
  • Wei T-C, Lin H-Y, Lu C-C, Chen C-M, You L-R. 2011. Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions. Gene Expression Patterns 11:384-394.
  • Weng S-Y, Yang C-Y, Li C-C, Sun T-P, Tung S-Y, Yen JJ-Y, Tsai T-F, Chen C-M, Chen SH, Hsiao M et al. 2011. Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. Journal of Hepatology 54: 685-694.
  • 期刊論文(2006-2010)

  • Chen, C.-M.*, Wang, H.-Y., You, L.-R., Shang, R.-L., Liu, F.-C. (2010) Expression analysis of an evolutionary conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon. Dev. Dyn. 239:1797-1806. * corresponding author
  • Liang, C.-C., You, L.R., Chang, J.-L., Tsai, T.-F., and Chen, C.-M.* (2009) Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs. J Biomed. Sci. 16:2. *corresponding author.
  • Chen, Y.-J., Chen, C.-M., Twu, N.-F., Yen, M.S., Lai, C.-R., Wu HH et al (2009). Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients. Virchows Arch 455: 431-440.
  • Cheon, D.-J., Wang, Y., Deng, J. M., Lu, Z., Xiao, L., Chen, C.-M., Bast, R. C., Jr., and Behringer, R. R. (2009). CA125/MUC16 Is Dispensable for Mouse Development and Reproduction. PLoS ONE 4: e4675.
  • Wang, Y., Cheon, D.J., Lu, Z., Cunningham, S.L., Chen, C.M., Luo, R.Z., Xing, D., Orsulic, S., Bast, R.C., Jr., and Behringer, R.R. (2008) MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse. Differentiation, 76(10):1081-1092.
  • Tsai, C.Y., Chou, C.K., Yang, C.W., Lai, Y.C., Liang, C.C., Chen, C.M., and Tsai, T.F. (2008) Hurp deficiency in mice leads to female infertility caused by an implantation defect. J. Biol. Chem. 283: 26302-26306.
  • Lu, T.-L., Chang, J.-L., Liang, C.-C., You, L.-R., and Chen, C.-M.* (2007) Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient Mice. PLoS ONE 2(11): e1237. *corresponding author.
  • Chao, C.-H., Chen, C.-M., Cheng, P.-L., Shih, J.-W., Tsou, A.-P., and Wu Lee, Y.-H. (2006) DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21 waf1/cip1 promoter, is a candidate tumor suppressor. Cancer Res. 66: 6579-6588.
  • Chang, J.-L.; Chen, T.-H.; Wang, C.-F.; Chiang, Y.-H.; Huang, Y.-L.; Wong, F.-H.; Chou, C.-K.*; Chen, C.M.* (2006) Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Exp. Cell Res. 312: 962-973. *co-corresponding authors.
  • 期刊論文(2001-2005)

  • Chen, C.-M. and Behringer, R.R. (2005) Ovca1 tumor suppressor gene. Curr Opin Genet Dev. 15:49-54.
  • Chen, C.-M., Chang, J.-L., and Behringer, R.R. (2004) Tumor formation in p53 mutant ovaries transplanted into wild-type female hosts. Oncogene, 23:7722-7725.
  • Chen, C.-M. and Behringer, R.R. (2004) Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev. 18:320-332.
  • Chen, S.-Y., Kao, C.-F., Chen, C.-M., Shih, C.-M., Hsu, M.-J., Chao, C.-H., Wang, S.-H, You, L-.R., and Wu Lee, Y.-H. (2003) Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein. J. Biol.Chem. 278:591-607.
  • Chen, C.-M. and Behringer, R. R. (2001) CREating breakthroughs. Nature Biotechnol. 19: 921 – 922. (News and Views)
  • Chen, C.-M. and Behringer, R. R. (2001) Cloning, structure, and expression of the mouse Ovca1 gene. Biochem. Biophys. Res. Commun. 286: 1019-1026.
  • Chou, S.-J., Chen, C.-M.,. Harn, H.-J.,.Chang, C.-L.,.Chen, C.-J., and Liu, Y.-C. (2001) In situ detection of hTERT mRNA relates to Ki-67 labeling index in papillary thyroid carcinoma. J. Surg. Res. 99: 75-83.
  • Liu, Y.-C, Chen, C.-M., Chen, C.-J., Hsieh, H.-F., Chang, C.-L., Shyu, J.-S., Yen, C.-Y., Harn, H.-J. (2001) Apoptosis and Fas-Ligand expression correlate to the histopathological grade of gastric smooth muscle tumors. J Surg Res. 95: 92-98.
  • 期刊論文(1995-2000)

  • Chen, C.-M., Chen, C. J., Chang, C.-L., Shyu, J.-S., Hsieh, H.-F., and Harn, H.-J. (2000) CD34, CD117 and actin expression in phyllodes tumor of the breast. J Surg Res. 94:84-91.
  • Grell, M., Zimmermann, G., Gottfried, E., Chen, C.-M., Gruenwald, U., Huang, D., Wu Lee, Y.-H., Duerkop, H, Engelmann, H., Scheurich, P., Wajant, H., and Strasser A. (1999) Induction of cell death by tumor necrosis factor (TNF) receptor 2, CD40 and CD30- a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J. 18: 3034-3043.
  • You, L.-R., Chen, C.-M., Yeh, T.-S., Tsai, T.-Y., Mai, R.-T, Lin, C.-H., and Wu Lee, Y.-H. (1999) Hepatitis C virus core protein interacts with cellular putative RNA helicase. J. Virol. 73: 2841-2852.
  • You, L.-R., Chen, C.-M., and Wu Lee, Y.-H. (1999) The hepatitis C virus core protein modulates the NF-kappa B signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor-alpha. J. Virol. 73: 1672-1681.
  • Chen, C.-M., You, L. -R., Hwang, L. H., and Wu Lee, Y.-H. (1997) Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor. J. Virol. 71: 9417-9426.
  • Shih, C.-M., Chen, C.-M., Chen, S.-Y., and Wu Lee, Y.-H.. (1995) Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation. J. Virol. 69: 1160-1171.