教師簡介

代表著作

  • Huang T-W, Chen T-L, Chen Y-T, Lauderdale T-L, Liao T-L, Lee Y-T, Chen C-P, Liu Y-M, Lin A-C, Chang Y-H, Wu K-M, Kirby R, Lai J-F, Tan M-C, Siu L-K, Chang C-M, Fung C-P, Tsai S-F. Copy number change of NDM-1 sequence in a multidrug resistant Klebsiella pneumoniae clinical isolate. PLoS One. 2013 Apr 29;8(4):e62774. doi: 10.1371/journal.pone.0062774. Print 2013.
  • Kirby R, Herron P, Hoskisson PA, Hunter I. Draft Genome Sequence of the Streptomyces rimosus Type Strain ATCC 10970, the Producer of Oxytetracycline. J. Bacteriol. (2013) 7;1(2):e0006313. doi: 10.1128/genomeA.00063-13
  • Tai L-R, Chou C-W, Lee I-F, Kirby R, Lin A. The quantatitive assessment of the role played by basic amino acid clusters in the nuclear uptake of human ribosomal protein L7. Experimental Cell Research (2013) 319:367-375.
  • Wu C-Y, Chen Y-F, Wang C-H, Kao C-H, Zhuang H-W, Chen C-C, Chen L-K, Kirby R, Wei Y-H, Tsai S-F, and Tsai T-F. A persistent level of Cisd2 extends healthy lifespan and delays aging in mice. Human Molecular Genetics (2012) 21:3956-3968.
  • Kirby R, Sangal V, Tucker NP, Zakrzewska-Czerwińska J, Wierzbicka K, Chu C-J, Chandra G, Fahal AH, Goodfellow M and Hoskisson PA. The draft genome sequence of the human pathogen Streptomyces somaliensis, a significant cause of actinomycetoma. J. Bacteriol. (2012) 194:3544-3545.
  • Kirby R. Chromosome Diversity and Similarity within the Actinomycetales. FEMS Microbiol Lett. (2011) 319:1-10.
  • Kirby R, Herron P, Hoskisson P. Analysis of developmental gene conservation in the Actinomycetales using DNA/DNA microarray comparisons. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology (2011) 99:159-177
  • Kirby R, Chen C. Genome Architechture. In Streptomyces: Molecular biology and biotechnology, Caister Academic Press, Editor Paul Dyson, (2010) Chapter 1.
  • Chou CW, Tai LR, Kirby R, Lee IF, Lin A. Importin β3 mediates the nuclear import of human ribosomal protein L7 through its interaction with the multifaceted basic clusters of L7. FEBS Lett. (2010) 584:4151-4156.
  • Ying-Fang Sun, Kirby R. The brain imaging finding of dyslexia. Journal of the Taiwan Pediatric Association. Pefiatr Neonatal (2010) 51:89-96
  • Ying-Fang Sun and Ralph Kirby. Candidate genes for dyslexia by an in Silico approach. Asian Journal of Health and Information Sciences (2009) 4:81-92.
  • Chen YF, Kao CH, Kirby R, Tsai TF. Cisd2 mediates mitochondrial integrity and life span in mammals. Autophagy. (2009) 5:1043-1045.
  • Shu HY, Fung CP, Liu YM, Wu KM, Chen YT, Li LH, Liu TT, Kirby R, Tsai SF. Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolates. Microbiology (2009) 155:4170-4183.
  • Wu K-M, Li L-H, Yan J-J, Tsao N., Liao T-L, Tsai L-C, Fung C-P, Chen H-J, Liu Y-M, Wang J-T, Fang C-T, Chang S-C, Shu H-Y, Liu T-T, Chen Y-T, Shiau Y-R, Lauderdale T-L, Su I-J, Kirby R. and Tsai S-F Genome Sequencing and Comparative Analysis of Klebsiella pneumoniae NTUH-K2044, a Strain Causing Liver Abscess and Meningitis J. Bacteriol. (2009) 191 4492-4501.
  • Hsiao Nai-hua and Ralph Kirby. Two-component signal transduction systems in Streptomyces and related organisms studied using DNA comparative microarray analysis. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology. (2009) 95:189-206.
  • Ralph Kirby, Teng-Kuei Gan, Emma Tilley, Paul Herron, Iain Hunter. The genome of Streptomyces rimosus subsp. rimosus shows a novel structure compared to other Streptomyces using DNA/DNA microarray analysis. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology (2008) 94:173-86.
  • Hsiao Nai-hua & Ralph Kirby. Comparative genomics of Streptomyces avermitilis, Streptomyces cattleya, Streptomyces maritimus and Kitasatospora aureofaciens using a Streptomyces coelicolor microarray system. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology (2008) 93, 1-25.
  • Lee LF, Chen YJ, Kirby R, Chen C, Chen CW. A multidrug efflux system is involved in colony growth in Streptomyces lividans. Microbiology. (2007) 153, 924-34.
  • Ko, J.-R., Wu, J.-I., Kirby, R., Lin A. Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function. FEBS Letters (2006) 580, 3804-3810.
  • Kirby, R. Thermophilic Actinomycetes and Lignin Degradation. Advances in Applied Microbiology (2006) 58, 125-168
  • Clarke, A.M., Kirby, R., Rose, P.D. Molecular microbial ecology of lignocellulose mobilisation as a carbon source in mine drainage wastewater treatment. Water SA (2004) 30, 658-661.
  • Kirby, R. DNA Evidence in South Africa: Fallacies and the Future. Obiter (2004) 25, 386-405.
  • Lai, W-L, Chou, L-Y, Ting, C-Y, Kirby, R, Tsai, Y-C, Wang, A, H-J, Liaw, S-H. The functional role of the binuclear meta; center of D-aminoacylase. Journal of Biological Chemistry (2004) 279, 13962–13967.
  • EOLSS – UNESCO Kirby, R, [2003], “Microbial Pathogenesis and Antibiotics” in 6.51.4, edited by R. Kirby, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford ,UK, [http://www.eolss.net]
  • EOLSS – UNESCO Kirby, R, [2003], “Prokaryote Genetics” in 6.51.4, edited by R. Kirby, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford ,UK, [http://www.eolss.net]
  • EOLSS – UNESCO Kirby, R, [2003], “Microbiology” in 6.51.4, edited by R. Kirby, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford ,UK, [http://www.eolss.net]
  • EOLSS – UNESCO Kirby, R, [2003], “Organelles and other Structures in Biology” in 6.51.2, edited by R. Kirby, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford ,UK, [http://www.eolss.net]
  • Davis, J.A., van Blerk, L.L., Kirby, R. & Hecht, T. — Genetic variation in the mud crab Scylla serrata (Forskål, 1775) (Crustacea: Portunidae) in South African estuaries. African Zoology (2003) 38, 343–350.
  • Kirby, R. Pitfalls of DNA profiling complete national populations for forensic purposes. Nature (London) Correspondence (2002) 419, 247.
  • Chen, CW, Huang, C-H, Lee, H-H, Tsai, H-H, Kirby, R. Once the circle has been broken: Dynamics and evolution of Streptomyces chromosomes. Trends in Genetics (2002) 18, 522-529.
  • EOLSS – UNESCO Kirby, R, [2002], “DNA as the Genetic Material” in 6.51.1 in 6.51, edited by R. Kirby, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford ,UK, [http://www.eolss.net]
  • EOLSS – UNESCO Kirby, R, [2002], “Fundamentals of Life” in 6.51, edited by R. Kirby, in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford ,UK, ISBN: 0-9534944-5-4 (hdbk), ISBN: 0-9534944-6-2 (CD), ISBN: 0-9534944-7-0 (The complete set). [http://www.eolss.net]
  • Kirby, R & Downing, T. The principles and problems of DNA profiling for legal purposes in South Africa. Obiter (2001) 22, 8-15.
  • Richner S, Meiring J & Kirby R. DNA profiling of Mycobacterium tuberculosis from the Eastern Cape Province of South Africa and the detection of a high level of genetic diversity. Electrophoresis (1999) 20, 1800-1806.
  • Nxomani C, Ribbink AJ, Kirby R. DNA profiling of Tilapia guinasana, a species endemic to a single sinkhole, to determine the genetic divergence between color forms. Electrophoresis (1999) 20 1781-1785.
  • Kharsany , Hoosen AA, Kiepiela P, Kirby R & Sturm AW. Phylogenetic analysis of Calymmatobacterium granulomatis based on 16S rRNA gene sequences. Journal of Medical Microbiology (1999) 48, 841-847.
  • da Serra, M., & Kirby, R. Development of Pleurotus ("Oyster") mushroom production in southern Africa using alien wood species as lignocellulose substrate. The International Journal of Mushroom Sciences (1999) 3, 49-55.
  • Krallis, M. & Kirby, R. Development of a PCR/Southern dot blot based detection system for the presence of genes involved in beta-lactam biosynthesis. Actinomycetologica (1998) 12, 15-28.
  • Chambers, R., McQuaid, C. & Kirby, R, RAPDs fingerprinting of southern African intertidal limpets, Siphonaria (Pulmonata: Gastropoda) with implications for the evolution of larval development. Journal of Experimental Marine Biology and Ecology (1998) 227, 49-66.
  • Kirby, R. A critical assessment of the new South African Genetically Modified Organisms Bill. BINAS News UNIDO (1997) 3, 12-14.
  • Kirby, R., Downing T. & Schwellnus, T. A critical assessment of the Genetically Modified Organisms Bill. Obiter (1997) 18, 89-98.
  • Richner, S.M., Miring, J. & Kirby, R. Differentiation between urban and rural populations of Mycobacterium tuberculosis using randomly amplified DNA - polymerase chain reaction (RAPD-PCR) Electrophoresis (1997) 1570-1576.
  • Kirby, R. & Da Serra, M. The utilization of invader Acacia woods for the production of the mushroom Pluribus. Food Processing Technologies for Africa: Emerging Technology Series, UNIDO. Ed Direr, H.A. (1997) 175-177.
  • Chambers, R., McQueen, C. & Kirby, R. Determination of the genetic diversity of the inertial limpets, Siphon aria (Gastropod, Culminate) by polyacrylamide gel electrophoresis (PAGE) of total cellular proteins. Journal of Experimental Marine Biology and Ecology (1996) 201, 1-11.
  • Kirby, R. Genetic Diversity in South Africa - Conservation and sustainable development. Genetic Engineering Monitor UNIDO, (1995) 2, 1-7.
  • Baxter, E., Rose, P.D. & Kirby, R. Age and population group related distribution of enteropathogens in the Eastern Cape, South Africa. Letter in Applied Microbiology (1994) 19, 442-445.
  • Hepburn, H.R., Jones, G.E., & Kirby R. Introgression between Apis mellifera capensis Escholtz and Apis mellifera scutellata Lepeletier: the sting hormones. Apidologie (1994) 25, 557-565.
  • Nxomani, C.D., Ribbink, A.J. & Kirby R. Differentiation of isolated threatened fish populations in dolomitic water by polyacrylamide gel electrophoresis of total proteins. Biological Conservation (1994) 69, 185-189.
  • Hatfill, S.J. & Kirby, R. normal mtDNA length polymorphisms in patients with the myelodysplastic syndrome. Blood (1994) 84, 314.
  • Hughes, FL, Rybicki, EP, Kirby, R. Complete nucleotide sequence of sugarcane streak Monogeminivirus. Arch Virol. 1993;132,171-82.
  • Gardee, Y. & Kirby R. The incidence of inducible MLS-resistance in methicillin resistant Staphylococcus aureus in clinical isolates from the Eastern Cape area of South Africa. Letters in Applied Microbiology (1993) 17, 264-268.
  • Hatfill, S.J., Le Cock, C.J. & Kirby R. A role for mitochondrial DNA in the pathogenesis of radiation induced MDS and secondary leukemia. Leukemia Research (1993) 17, 907-913
  • Kirby, R. The isolation and characterization of antibiotic biosynthesis genes. Biotechnology Advances (1992) 10, 561-576.
  • Hatfill, S.J., Bohm, L., Downing, T.G. & Kirby, R. Mitochondrial DNA mutations in the myelodysplastic syndrome Lancet (1992) 340, 370.
  • Kirby, R. Evolutionary origin of Class A and Class C beta lactamases. Journal of Molecular Evolution (1992) 34, 345-350.
  • Bourn, W.R. & Kirby, R. Time dependent changes in the DNA-binding proteins of Streptomyces coelicolor A3(2). Actinomycetologica (1991) 5, 10-13.
  • Hughes, F.L., Rybicki, E.P., Kirby, R. & von Wechmar, M.B. Characterization of the Sugar Cane Streak agent as a distinct Geminivirus. Intervirology (1991) 32, 19-27.
  • Hart, S., Kirby, R. & Woods, D.R. Structure of the Rhodococcus gene encoding pigment production in Escherichia coli. Journal of General Microbiology (1990) 136, 1357-1363.
  • Kirby, R. Evolutionary origin of aminoglycoside phosphotransferase resistance genes. Journal of Molecular Evolution (1990) 30:489-492.
  • Hatfill, S.J., Kirby, R., Hanley, M., Rybicki, E.P. & Bohm, L. Hyperprolactinemia in acute myeloid leukaemia and indications of ectopic expression of human prolactin in bast cells of a patient of subtype M4. Leukaemia Research (1990) 14, 57-62.
  • Hatfill, S.J., Williamson, C., Kirby, R. & van Wechmar, M.B. Identification and localization of aphid lethal paralysis virus particles in thin tissue sections of Rhopalosiphum padi by in situ nucelic acid hybridization. Journal of Invertebrate Pathology (1990) 55, 265-271.
  • Hill, R.T., Hart, S. Illing, N., Ravenscroft, N., Kirby, R. & Woods, D.R. Cloning and expression of Rhodococcus pigment genes in Escherichia coli. Journal of General Microbiology (1989) 135, 1505-1513.
  • Clarke, B. Rybicki, E.P., Kirby, R. & von Wechmar, M.B. Characterisation of Southern African isolates of Maize Streak Virus: differentiation of three isolates by serology and their typing by restriction mapping. Intervirology (1989) 30, 96-101.
  • Clarke, B., Rybicki, E.P. & Kirby, R. Evolution of natural Maize Streak Virus isolates in Southern Africa. Intervirology (1989) 30, 90-95.
  • Hill, R.T., Illing, N. Kirby, R. & Woods, D.R. Development of pRL591, a Streptomyces - Escherichia coli positive selection shuttle vector. FEMS Microbiology Letters (1989) 57, 223-226.
  • Hromic, A. & Kirby, R. Isolation and study of two mutants of Streptomyces cattleya affecting DNA repair and instability. FEMS Microbiology Letters (1989) 57, 139-143.
  • Becker I.I. & Kirby, R. A study of Hake populations using restriction endonuclease analysis of the mitochondrial DNA. A practical application of molecular biology to a South African taxonomic problem. Transactions of the Royal Society of South Africa (1988) 46:4, 313-316.
  • Becker, I.I., Grant, W.S., Kirby, R. & Robb, F.T. Evolutionary divergence between sympatric species of southern African Hakes, Merluccius capensis and Merluccius paradoxus. II. Mitochondrial DNA sequence divergence. Heredity (1988) 61, 21-30.
  • Usdin, K. & Kirby, R. Cloning of repeated DNA sequences from Streptomyces cattleya. FEMS Microbiology Letters (1988) 50, 201-205.
  • Pretorius I-M, Rawlings, D.E., O'Neill, E.G., Jones, W.A., Kirby, R. & Woods, D.R. Nucleotide sequence of the gene encoding the nitogenase iron protein of Thiobacillus ferrooxidans Journal of Bacteriology (1987) 487, 367-370.
  • Kirby, R. & Rybicki, E.P. Enzyme Linked Immunosorbent Assay (ELISA) as a means of taxonomic analysis of Streptomyces and related organisms. Journal of General Microbiology (1986) 132, 1891-1894.
  • Walter, C.B., O'Neill, E. & Kirby, R. "ELISA" as an aid to the identification of fish and molluscan prey in birds in marine ecosystems. Journal of Experimental Marine Biology and Ecology (1986) 96, 97-102.
  • Coyne, V.E. & Kirby, R. VC11: an actinophage virulent to Streptomyces cattleya and Streptomyces olivaceus. Intervirology (1986) 25, 61-68.
  • Usdin, K. & Kirby, R. The loss of a large DNA fragment. Is associated with the aerial mycelium negative (Amy-) phenotype of Streptomyces cattleya. Journal of General Microbiology (1985) 131, 979-981.
  • Kirby, R. & Usdin, K. The isolation and restriction mapping of a miniplasmid from the Actinomycete Nocardia corallina. FEMS Microbiology Letters (1985) 27, 57-59.
  • Usdin, K., Gertsch, K. & Kirby R. Evidence for the wide distribution of repetitive DNAA sequences in the genus Streptomyces. Journal of Molecular Evolution (1984) 20, 20-30.
  • Coyne, V.E., Usdin, K. & Kirby, R. The effect of inhibitors of DNA repair on the genetic stability of Streptomyces cattleya. Journal of General Microbiology (1984) 130, 887-892.
  • Hanssen, R. & Kirby, R. The induction by N'-Methyl-N'Nitro-N'nitrosoguanidine of multiple closely linked mutations in Streptomyces bikiniensis ISP 5235 affecting streptomycin resistance and streptomycin biosynthesis. FEMS Microbiology Letters (1983) 13, 79-82.
  • Kirby, R., Lewis, E. and Botha, C. A survey of Streptomyces species for covalently closed circular (ccc) DNA using a variety of methods. FEMS Microbiology Letters (1982) 13, 79-82.
  • Kirby, R. & Lewis E. Unstable genetic elements affecting streptomycin resistance in the streptomycin producing organisms Streptomyces griseus NCIB 8506 and Streptomyces bikiniensis ISP 5235. Journal of General Microbiology (1981) 122, 351-355.
  • Kirby, R. & Wotton, S.F. Restriction studies on the SCP2 plasmid of Streptomyces coelicolor A3(2). FEMS Microbiology Letters (1979) 6, 321-324.
  • Flett, F., Wotton, S.F. & Kirby, R. A common host specificity in the restriction modification of a bacteriophage by three distinct Streptomyces species. Journal of General Microbiology (1979) 110, 465-467.
  • Kirby R. An unstable genetic element affecting the production of the antibiotic holomycin by Streptomyces clavuligerus. FEMS Microbiology Letters (1978) 3, 283-286.
  • Kirby, R. Genetic mapping of Streptomyces clavuligerus. FEMS Microbiology Letters (1978) 3, 177-180.
  • Kirby, R. & Hopwood, D.A. Genetic determination of methylenomycin synthesis and resistance by the SCP1 plasmid of Streptomyces coelicolor A3(2). Journal of General Microbiology (1977) 98, 239-252.
  • Kirby, R., Wright, L.F. & Hopwood, D.A. Plasmid-determined antibiotic synthesis and resistance in Streptomyces coelicolor. Nature (London), (1975) 254, 265-267.

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