教師簡介

代表著作

  • Lin CH, Shen YA, Hung PH, Yu YB, Chen YJ. Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines. BMC Complement Altern Med. 2012 Oct 30;12(1):201.
  • Lin CS, Lee HT, Lee SY, Shen YA, Wang LS, Chen YJ, Wei YH. High mitochondrial DNA copy number and bioenergetic function are associated with tumor invasion of esophageal squamous cell carcinoma cell lines. Int J Mol Sci. 2012;13(9):11228-46.
  • Lo FY, Chang JW, Chang IS, Chen YJ, Hsu HS, Huang SF, Tsai FY, Jiang SS, Kanteti R, Nandi S, Salgia R, Wang YC.The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization. BMC Cancer. 2012 Jun 12;12(1):235.
  • Liao HM, Chao YL, Huang AL, Cheng MC, Chen YJ, Lee KF, Fang JS, Hsu CH, Chen CH Identification and characterization of three inherited genomic copy number variations associated with familial schizophrenia. Schizophr Res. 2012 Aug;139(1-3):229-36.
  • Liao HM, Niu DM, Chen YJ, Fang JS, Chen SJ, Chen CH Identification of a microdeletion at Xp22.13 in a Taiwanese family presenting with Nance-Horan syndrome. J Hum Genet. 2011 Jan;56(1):8-11.
  • Yew TL, Chiu FY, Tsai CC, Chen HL, Lee WP, Chen YJ, Chang MC, Hung SC Knockdown of p21(Cip1/Waf1) enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells. Aging Cell. 2011 Apr;10(2):349-61.
  • Yen CC, Tsao YP, Chen PC, Wu YC, Liu JH, Pan CC, Liu CY, Tzeng CH, Chen PM, Chen YJ, Lin CH, Hsu WH. PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery. J Surg Oncol 2011;103:761-7.
  • Tsai CC, Chen YJ, Yew TL, Chen LL, Wang JY, Chiu CH, Hung SC. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST. Blood. 2011 Jan 13;117(2):459-69.
  • Chen CF, Hsu EC, Lin KT, Tu PH, Chang HW, Lin CH, Chen YJ, Gu DL, Lin CH, Wu JY, Chen YT, Hsu MT, Jou YS. Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma. Hepatology. 2010 Nov;52(5):1690-701.
  • Cheng KH, Liu MY, Kao CH, Chen YJ, Hsiao KJ, Liu TT, Lin HY, Huang CH, Chiang CC, Ho HJ, Lin SP, Lee NC, Hwu WL, Lin JL, Hung PY, Niu DM. Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. J Chin Med Assoc. 2010 Jun;73(6):314-8.
  • Hsu YH, Liao LJ, Yu CH, Chiang CP, Jhan JR, Chang LC, Chen YJ, Lou PJ, Lin JJ. Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts. J Biol Chem. 2010 Jul 16;285(29):22630-8.
  • Chen CP, Lin SP, Chern SR, Chen YJ, Tsai FJ, Wu PC, Wang W. Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay. Eur J Med Genet. 2010 Jul-Aug;53(4):217-20.
  • Chien WH, Gau SS, Wu YY, Huang YS, Fang JS, Chen YJ, Soong WT, Chiu YN, Chen CH. Identification and molecular characterization of two novel chromosomal deletions associated with autism. Clin Genet. 2010 Nov;78(5):449-56.
  • Wong FH, Huang CY, Su LJ, Wu YC, Lin YS, Hsia JY, Tsai HT, Lee SA, Lin CH, Tzeng CH, Chen PM, Chen YJ, Liang SC, Lai JM, Yen CC. Combination of microarray profiling and protein-protein interaction databases delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma. International journal of oncology 2009;34(1):117-128.
  • Yen CC, Chen WM, Chen TH, Chen WY, Chen PC, Chiou HJ, Hung GY, Wu HT, Wei CJ, Shiau CY, Wu YC, Chao TC, Tzeng CH, Chen PM, Lin CH, Chen YJ, Fletcher JA. Identification of chromosomal aberrations associated with disease progression and a novel 3q1331 deletion involving LSAMP gene in osteosarcoma. International journal of oncology 2009;35(4):775-788.
  • Lu KH, Chen YW, Tsai PH, Tsai ML, Lee YY, Chiang CY, Kao CL, Chiou SH, Ku HH, Lin CH, Chen YJ.. Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancer stem-like cells. Childs nervous system 2009;25(5):543-50.
  • Tsai LP, Liao HM, Chen YJ, Fang JS, Chen CH.. A novel microdeletion at chromosome 2q311-312 in a three-generation family presenting duplication of great toes with clinodactyly. Clinical genetics 2009;75(5):449-456.
  • Pan CC, Chen YJ, Chang LC, Chang YH, Ho DM. Immunohistochemical and molecular genetic profiling of acquired cystic disease-associated renal cell carcinoma. Histopathology 2009;55(2):145-153.
  • Wu TC, Liu HH, Chen YJ, Tang RB, Hwang BT, Yuan HC. Comparison of clinical features of childhood norovirus and rotavirus gastroenteritis in taiwan. J Chin Med Assoc. 2008;71(11):566-570.
  • Chiou SH, Kao CL, Chen YW, Chien CS, Hung SC, Lo JF, Chen YJ, Ku HH, Hsu MT, Wong TT.. Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. PLoS ONE 2008;3(5):e2090
  • Chen CP, Chen YJ, Chern SR, Tsai FJ, Lin HH, Lee CC, Wang W.. Prenatal diagnosis of mosaic 1q313q321 trisomy associated with occipital encephalocele. Prenatal Diagnosis 2008;28(9):865-867.
  • Chen CP, Chen YJ, Chern SR, Tsai FJ, Chang TY, Lee CC, Town DD, Lee MS, Wang W.. Prenatal diagnosis of concomitant Wolf-Hirschhorn syndrome and split hand-foot malformation associated with partial monosomy 4p (4p161-->pter) and partial trisomy 10q (10q251-->qter). Prenatal Diagnosis 2008;28(5):450-453.
  • Chen CP, Chen YJ, Tsai FJ, Chern SR, Wang W.. NFkappaB2 gene duplication is associated with fetal pyelectasis in partial trisomy 10q (10q241 --> qter). Prenatal Diagnosis 2008;28(4):364-365.
  • Yen CC, Liang SC, Jong YJ, Chen YJ, Lin CH, Chen YM, Wu YC, Su WC, Huang CY, Tseng SW, Whang-Peng J.. Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: Different cytogenetic changes are correlated with genders and smoking habits. Lung Cancer 2007;57(3):292-301.
  • Chen CP, Wang TH, Chen YJ, Chang TY, Liu YP, Tzen CY, Chern SR, Wang W.. Prenatal diagnosis of Fryns syndrome associated with a microdeletion at 8p231. Prenatal diagnosis 2007;27(10):967-9.
  • Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Hwang SF, Chen YM.. Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology 2007;46(5):1413-1425.
  • Pan CC, Jong YJ, Chai CY, Huang SH, Chen YJ.. Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm. Human Pathology 2006;37(5):606-12.
  • Lian WN, Wu TW, Dao RL, Chen YJ, Lin CH.. Deglycosylation of Na+/K+-ATPase causes the basolateral protein to undergo apical targeting in polarized hepatic cells . Journal of Cell Science 2006;119(Pt 1):11-22.
  • Liu CJ, Lin SC, Chen YJ, Chang KM, Chang KW.. Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas. Molecular carcinogenesis 2006;45(10):721-31.
  • Niu DM, Huang JY, Li HY, Liu KM, Wang ST, Chen YJ, Udaka T, Izumi K, Kosaki K.. Paternal gonadal mosaicism of NIPBL mutation in a father of siblings with Cornelia de Lange syndrome. Prenatal diagnosis 2006;26(11):1054-1057
  • Chen CP, Lin SP, Wang TH, Chen YJ, Chen M, Wang W.. Perinatal findings and molecular cytogenetic analyses of de novo interstitial deletion of 9q (9q223-->q313) associated with Gorlin syndrome. Prenatal diagnosis 2006;26(8):725-729
  • Chen CP, Lin SP, Lin CC, Chen YJ, Chern SR, Li YC, Hsieh LJ, Lee CC, Pan CW, Wang W. Molecular cytogenetic analysis of de novo dup(5)(q352q353) and review of the literature of pure partial trisomy 5q. American journal of medical genetics part a 2006;140(14):1594-1600.
  • Kao CL, Chiou SH, Ho DM, Chen YJ, Liu RS, Lo CW, Tsai FT, Lin CH, Ku HH, Yu SM, Wong TT.. Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor. American Journal of Clinical Pathology 2005;123(2):297-304.
  • Pan CC, Jong YJ, Chen YJ.. Comparative Genomic Hybridization Analysis of Thymic Neuroendocrine (Carcinoid) Tumors . Modern Pathology 2005;18(3):358-64.
  • Kao CL, Chiou SH, Chen YJ, Singh S, Lin HT, Liu RS, Lo CW, Yang CC, Chi CW, Lee CH, Wong TT.. Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system. Modern Pathology 2005;18(6):769-78.
  • Hung KS, Hwang SL, Liang CL, Chen YJ, Lee TH, Liu JK, Howng SL, Wang CH.. Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. Journal of neuropathology and experimental neurology 2005;64(1):15-26.
  • Yen CC, Chen YJ, Pan CC, Lu KH, Chen PC, Hsia JY, Chen JT, Wu YC, Hsu WH, Wang LS, Huang MH, Huang BS, Hu CP, Chen PM, Lin CH. Copy number changes of target genes in chromosome 3q253-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed. World Journal of Gastroenterology 2005;11(9):1267-72.
  • Jiang JK, Chen YJ, Lin CH, Yu IT, Lin JK.. Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases--an analysis by comparative genomic hybridization. Genes, Chromosomes & Cancer 2005;43(1):25-36.
  • Chien JC, Chen SJ, Tiu CM, Chen YJ, Hwang B, Niu DM.. Is urorectal septum malformation sequence a variant of the vertebral defects, anal atresia, tracheo-oesophageal fistula, renal defects and radial dysplasia association? Report of a case and a review of the literature. European Journal of Pediatrics 2005;164(6):350-4.
  • Jong YJ, Li LH, Tsou MH, Chen YJ, Cheng SH, Wang-Wuu S, Tsai SF, Chen CM, Huang AT, Hsu MT, Lin CH.. Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations. Cancer Genetics & Cytogenetics 2004;148(1):55-65.
  • Shiue CN, Lin YH, Kuan LC, Lii LM, Tsai WH, Chen YJ, Lin SJ, Kuo PL.. Cytogenetic surveillance of mentally-retarded school children in southern Taiwan. Journal of the Formosan Medical Association 2004;103(3):218-24.
  • Wang CH, Chen YJ, Lee TH, Chen YS, Jawan B, Hung KS, et al.. Protective effect of MDL28170 against thioacetamide-induced acute liver failure in mice . Journal of biomedical science 2004;11(5):571-8.
  • Lin SC, Liu CJ, Chiu CP, Chang SM, Lu SY, Chen YJ.. Establishment of OC3 oral carcinoma cell line and identification of NF-kappa B activation responses to areca nut extract. Journal of oral pathology & medicine 2004;33(2):79-86.
  • Chen YJ, Lin SC, Kao T, Chang CS, Hong PS, Shieh TM, Chang KW.. Genome-wide profiling of oral squamous cell carcinoma . Journal of Pathology 2004;204(3):326-32.
  • Wang CH, Jawan B, Lee TH, Hung KS, Chou WY, Lu CN, Liu JK, Chen YJ.. Single injection of naked plasmid encoding α-melanocyte-stimulating hormone protects against thioacetamide-induced acute liver failure in mic. Biochemical and Biophysical Research Communications 2004;322(1):153-61.
  • Wang CH, Lee TH, Tsai YJ, Liu JK, Chen YJ, Yang LC, Lu CY.. Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats. Acta pharmacologica Sinica 2004;25(8):1027-30.
  • Chen CK, Chang SD, Chen YJ, Hsueh DW, Soong YK. Comparative genomic hybridization-assisted prenatal diagnosis of a de novo inverted duplication of chromosome 10q A case report. Journal of reproductive medicine 2003;48(5):391-4.
  • Yen MY, Chen YJ, Lin CH, Wang AG, Wei YH. Genetic analysis in Leber's hereditary optic neuropathy using the comparative genomic hybridization technique. Clinical & experimental ophthalmology 2003;31(5):435-438.
  • Sung YJ, Sung Z, Ho CL, Lin MT, Wang JS, Yang SC, Chen YJ, Lin CH.. Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells. Experimental cell research 2003;287(2):209-18.
  • Yen CC, Chen YJ, Lu KH, Hsia JY, Chen JT, Hu CP, Chen PM, Liu JH, Chiou TJ, Wang WS, Yang MH, Chao T. Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. International Journal of Oncology 2003;23(4):871-81.
  • Chen YJ, Chen PJ, Lee MC, Yeh SH, Hsu MT, and Lin CH. Chromosomal analysis of hepatic adenoma and focal nodular hyperplasia by comparative genomic hybridization . Genes, Chromosomes & Cancer 2002;35:138-143.
  • Lin SC, Chen YJ, Kao SY, Hsu MT, Lin CH, Yang SC, Liu TY, Chang KW. Chromosomal changes in betel-associated oral squamous cell carcinomas and their relationship to clinical parameters. Oral oncology 2002;38:266-73.
  • Yen CC, Chen YJ, Chen JT, Hsia JY, Chen PM, Liu JH, Fan FS, Chiou TJ, Wang WS, Lin CH.. Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis. Cancer 2001;92:2769-77.
  • Yang YC, Shyong WY, Chang MS, Chen YJ, Lin CH, Wang TY, Hsu MT, and Chen ML.. Frequent gain of copy number on the long arm of chromosome 3 in human cervical adenocarcinoma. Cancer Genetics & Cytogenetics 2001;131:48-53.
  • Lin WH, Huang CJ, Liu MW, Chang HM, Chen YJ, Tai TY, Chuang LM.. Cloning, Mapping, and Characterization of the Human Sorbin and SH3 Domain Containing 1 (SORBS1) Gene: A Protein Associated with c-Abl during Insulin Signaling in the Hepatoma Cell Line Hep3B. Genomics 2001;1:12-20.
  • Chen YJ, Yeh, SH., Chen, JT., Wu,CC., Hsu, MT., Tsai, SF., Chen, PJ., and Lin, CH.. Chromosomal Changes and Clonality Relationship between Primary and Recurrent Hepatocellular Carcinoma. Gastroenterology 2000;119:431-440.
  • Chen, YJ., Ko, JY., Chen, PJ., Shu, CH., Hsu, MT., Tsai, SF., Lin, CH.. Chromosomal Aberrations in Nasopharygeal Carcinoma Analyzed by Comparative Genomic Hybridization. Genes, Chromosomes & Cancer 1999;25:169-175.