教師簡介

  • 兼任副教授
  • 張久瑗
  • Dr. Chen, Joanne Jeou-Yuan
  • Tel. 02-27899046/Fax. 02-27858594
  • 中央研究院生物醫學研究所
  • 個人網站
  • https://www.ibms.sinica.edu.tw/pi_webpage/blue_style2016/index.php?p_id=48&journal_info_sysid=104439
  • 專業領域
  • Cancer Genomics, Molecular Oncology
  • 研究介紹
  • 為了進一步瞭解腸胃道腫瘤發生、進展及惡化的機制,我們利用代表性差異展示法,分離出兩千多種在胃癌組織呈現差異表現性的基因,將其製成胃癌晶片,利用cDNA微陣列及群組分析,確認與胃癌病變有密切關連的基因及訊息傳遞路徑,進而探討其參與調控細胞增生、存活與遷移的分子機制,並以動物模式來瞭解其在癌症病變及轉移中所扮演的角色;目前我們深入研究的主體包含Osteopontin/CD44訊息傳遞調控腫瘤與其周遭環境互動的機制,Suppressor of cytokine signaling 6 (SOCS6) 對粒線體功能及細胞凋亡的影響,及Rho 的交互蛋白 Rhotekin對細胞移動及存活的調控;我們希望這些研究能讓我們更了解癌症致病及惡化的機轉,並提供癌症病患較佳的診斷及預後的標誌,最終極的目的是希望能促進我們瞭解、治療及預防癌症的方針。

  • 教授科目
  • 癌症生物學
  • 經歷
  • present
    中央研究院生物醫學研究
    研究員
  • present
    國立陽明大學
    生命科學系暨基因體科學研究所
    兼任教授
  • 學歷
  • 美國明尼蘇達大學
    生化 博士

代表著作(過去五年)

  • Guo JY, Hsu HS, Tyan SW, Li FY, Shew JY, Lee WH, Chen JY. (2017) Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner. Oncogene. 36:2457-2471. doi:10.1038/onc.2016.404.
  • Yao NW, Chang C, Lin HT, Yen CT, Chen JY. (2016) Functional assessment of glioma pathogenesis by in vivo multi-parametric magnetic resonance imaging and in vitro analyses. Scientific Reports. 6:26050. doi: 10.1038/srep26050.
  • Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY*, Gazdar AF*. (2016) ITPKA gene body methylation regulates gene expression and serves as an early diagnostic marker in lung and other cancers. J Thoracic Oncol. 11:1469-1481. doi: 10.1016/j.jtho.2016.05.010. (*: equal contribution)
  • Sudhir PR, Lin ST, Chien CW, Yang SH, Li AFY, Li RH, Wang MJ, Chen YT, Chen CF, Jou YS, Chen JY. (2015) Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence. Scientific Reports. 5:9633-9641.
  • Chen CC, Hsu YH, Jayaseema DM, Chen JY, Hueng DY, Chang C (2015) White matter tracts for the trafficking of neural progenitor cells characterized by cellular MRI and immunohistology: the role of CXCL12/CXCR4 signaling. Brain structure & function 220(4), 2073-2085.
  • Tiong KL, Chang KC, Yeh KT, Liu TY, Wu JH, Hsieh PH, Lin SH, Lai WY, Hsu YC, Chen JY, Chang JG, Shieh GS (2014) CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis. Neoplasia 16(5), 441-450.
  • Sudhir PR, Chen JY. (2014) Functional Phosphoproteomics of Oncogenic KRAS Signaling. Methods Mol Biol. 1120:157-166.
  • Lin HY, Lai RH, Lin ST, Lin RC, Wang MJ, Lin CC, Wang FF, Chen JY. (2013) Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation to mitochondria. Cell Death & Differentiation. 20:139-153
  • Sudhir PR, Chen CH, Pavana Kumari M, Wang MJ, Tsou CC, Sung TY, Chen JY, Chen CH (2012) Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells. Molecular & cellular proteomics : MCP 11(10), 901-915
  • Sudhir, P.-R., Hsu, C.-L., Wang, Y.-T., Chen, Y.-J., Sung, T.-Y., Hsu, W.-L., Yang, U.-C., and Chen, J.-Y. (2011) Phosphoproteomics identifies oncogenic Ras signaling targets and their involvement in lung adenocarcinomas. PLoS One 6(5), e20199