教師簡介

  • 專任教授兼所長及系主任
  • 林照雄
  • Chao-Hsiung Lin
  • 02-2826-7000 ext.7280/lab: ext. 5777 or 5786
  • 傳統醫學大樓甲棟1樓R112
  • 專業領域
  • Metabolomics, Proteomics, Post-translational modifications, Mass spectrometry & Chemical biology
  • 研究方向
  • 癌細胞相關蛋白的功能研究: Primary interest of my lab is to study protein functions through diverse omics techniques as well as chemical biology. Current focus is the hnRNPK protein that participates in many cell events, including chromatin recruiting, transcription regulation, RNA splicing and translation regulation. Moreover, amplification of hnRNPK is associated with cancer progression, migration and prognosis. Recently, we demonstrated that two essential arginine methylation of hnRNPK is able to suppress the apoptotic induction of DNA damage in cancer cells. The mechanism regarding how these arginine methylation help cancer cells survive from apoptosis is under study.

    長壽基因的作用機制探討: Cisd2 is a mitochondrial/ER protein demonstrated by Prof. Ting-Fen Tsai (Department of Life Sciences and Institute of Genome Sciences, NYMU) for its close correlation with aging process in mice model. Our investigation of Cisd2 knockout and transgenic mice using proteomics and metabolomics approaches has identified several pathways that might be associated with the progress of aging in these animal models. Current focus is to illustrate the pathways that are involved in aging process.

    以人類血液代謝體研究發展老化指標分子: In addition to aging animal models, we have collaborated with physicians at Taipei Veteran’s General Hospital to search serum metabolites as candidate biomarkers for aging. Among 160 blood samples of donors ranging from healthy youngsters, healthy elders to elders with mild cognition impairment or Alzheimer’s disease in both genders, we have picked up several metabolites strongly associated with aging process or neural degeneration. Current focus is to evaluate the potential of these metabolites as aging markers.

    抗癌天然物穿心蓮內酯的分子藥理機制: Andrographolide is a major component of Andrographis paniculata leaves employed for medicinal use, including the anti-inflammatory and neuroprotective activities. Through collaboration with Prof. Shu-Ling Fu (Institute of Traditional Medicine, NYMU), we have demonstrated that andrographolide can transcriptionally down-regulate a triglyceride esterase and thus suppress migration of cancer cells. The mechanism regarding how substrate and product of such esterase affects the biological function of andrographolide is under study.

  • 教授科目
  • 有機化學
    有機化學實驗
    化學生物學─蛋白體與代謝體研究方法
    高等蛋白質體學
    分子酵素學
    生命科學技術
  • 經歷
  • Aug. 2015-present
    國立陽明大學
    生命科學系暨基因體科學研究所
    所長
  • Feb. 2014-present
    國立陽明大學
    生命科學系暨基因體科學研究所
    教授
  • Aug. 2007-Jan. 2014
    國立陽明大學
    生命科學系暨基因體科學研究所
    副教授
  • Aug. 1998-Jul. 2007
    國立陽明大學生命科學系
    助理教授
  • Nov. 1995-Jul. 1998
    美國加州Scripps研究所化學系
    博士後研究
  • Aug. 1989-Jul. 1990
    國立臺灣大學化學系
    研究助理
  • 學歷
  • Sep. 1990-Oct. 1995
    美國紐約州立大學石溪分校化學系
    博士
  • Sep. 1983-Jun. 1987
    國立臺灣大學化學系
    學士

代表著作(過去五年)

  • Wei-Ting Liu, Wu-Chun Tu, Chao-Hsiung Lin, Ueng-Cheng Yang, Cheng-Chen Chen* 2017, Nov. "Involvement of cecropin B in the formation of the Aedes aegypti mosquito cuticle" Scientific Reports, in press.
  • Yi-Long Huang, Zhao-Qing Shen, Chia-Yu Wu, Yuan-Chi Teng, Chen-Chung Liao, Cheng-Heng Kao, Liang-Kung Chen, Chao-Hsiung Lin*, Ting-Fen Tsai* 2017, Nov. "Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging" Aging Cell, in press.
  • Wei-Hung Tan, Shu-Chun Cheng, Yu-Tung Liu, Cheng-Guo Wu, Min-Han Lin, Chiao-Che Chen, Chao-Hsiung Lin, Chi-Yuan Chou* 2016, Aug. " Structure of a Highly Active Cephalopod S-crystallin Mutant: New Molecular Evidence for Evolution from an Active Enzyme into Lens-Refractive Protein" Scientific Reports, 31176.
  • Ya-Hsin Hsu , Yu-Ling Hsu , Sheng-Hung Liu, Hsin-Chia Liao, Po-Xuan Lee, Chao-Hsiung Lin, Lee-Chiang Lo, Shu-Ling Fu* 2016, Apr. "Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study" PLoS ONE, e0152770.
  • Yao-Ping Lin, Wen-Chung Yu, Meng-Erh Hsu, Hsiao-Chien Tsai, Chen-Chung Liao*, Chao-Hsiung Lin 2015, Apr. "Comparative proteomic analysis of rat left ventricle in a subtotal nephrectomy model" J Chin Med Assoc, 218-228.
  • Yi-Ling Wang, Gan-Guang Liou, Chao-Hsiung Lin, Mong-Liang Chen, Tzer-Min Kuo, Kuen-Nan Tsai, Chien-Choao Huang, Ya-Ling Chen, Li-Rung Huang, Yu-Chi Chou, Chungming Chang* 2015, Mar. " The inhibitory effect of the hepatitis B virus singly-spliced RNA-encoded p21.5 protein on HBV nucleocapsid formation" PLoS ONE, e0119625.
  • Jen-Hao Yang, Yi-Ying Chiou, Shu-Ling Fu, I-Yun Shih, Tsai-Hsuan Weng, Wey-Jinq Lin, and Chao-Hsiung Lin* 2014, Nov. "Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation" Nucleic Acids Res, 9908-9924.
  • Min-Han Lin, Shang-Ju Chuang, Chiao-Che Chen, Shu-Chun Cheng, Kai-Wen Cheng, Chao-Hsiung Lin, Chiao-Yin Sun*, and Chi-Yuan Chou* 2014, Jun. "Structural and functional characterization of MERS coronavirus papain-like protease" Journal of Biomedical Science, 54.
  • Yan-Su Lin, Yi-Long Huang, Wen-Fu Lee*, and Chao-Hsiung Lin* 2014, May "Property and Application of BACy-Based Functional Hydrogels" Journal of the Chinese Chemical Society, 945-952.
  • Chih-Hao Wang, Yi-Fan Chen, Chia-Yu Wu, Pei-Chun Wu, Yi-Long Huang, Cheng-Heng Kao, Chao-Hsiung Lin, Lung-Sen Kao, Ting-Fen Tsai*, and Yau-Huei Wei* 2014, May "Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis" Human Molecular Genetics, 4770-4785.
  • Sheng-Hung Liu, Chao-Hsiung Lin, Fong-Ping Liang, Pei-Fen Chen, Cheng-Deng Kuo, Mohd. Mujahid Alam, Barnali Maiti, Shih-Kai Hung, Chin-Wen Chi, Chung-Ming Sun* and Shu-Ling Fu* 2014, Jan. "Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy" Biochemical Pharmacology, 229-242.
  • Yan-Su Lin, Chao-Hsiung Lin, and Wen-Fu Lee* 2014, Jan. "Investigation of the synthesis and properties of the copolymeric hydrogels based on N-isopropyl acrylamide and acrylamidoazo- benzene" Journal of Polymer Research, 364.
  • Fong-Lee Huang, Young-Ji Shiao, Sheue-Jane Hou, Cheng-Ning Yang, Yi-Jen Chen, Chao-Hsiung Lin, Feng-Shiun Shie and Huey-Jen Tsay* 2013, Aug. "Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization" Journal of Biomedical Science, 54.
  • Yong-Shiang Lin, Chao-Hsiung Lin, Li-De Huang, Tung Chao, Cheng-Deng Kuo, Ling-Chien Hung, Fen-Hwa Wong, Chun-Cheng Lin* and Shu-Ling Fu* 2013, Jul. "The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent" Biochemical Pharmacology, 242-252.
  • Sheng-Hui Tsai, Gwan-Han Shen, Chao-Hsiung Lin, Jiue-Ru Liau, Hsin-Chih Lai, and Shiau-Ting Hu* 2013, Jun. "Mab_3168c, a Putative Acetyltransferase, Enhances Adherence, Intracellular Survival and Antimicrobial Resistance of Mycobacterium abscessus" PLoS ONE, e67563.
  • Kai-Wei Hsueh, Shu-Ling Fu, Chirn-Bin Chang, Yu-Ling Chang and Chao-Hsiung Lin* 2013, Feb. "A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2" BBA-Proteins and Proteomics, 508-515.
  • Yan-Su Lin, Hsuan-Hsuan Lee, Wen-Fu Lee and Chao-Hsiung Lin* 2013, Feb. "Synthesis and qualitative analysis of BACy and its self-polymer" Journal of the Chinese Chemical Society, 223-228.
  • Chih-Liang Tien, Chao-Hsiung Lin, Ting-Hui Lin, Feng-Chen Wen, Chien-Wei Su, Sheng-Seen Fan and Mingli Hsieh* 2012, Sep. " Secreted cyclophilin A induction during embryo implantation in a model of human trophoblast-endometrial epithelium interaction" European Journal of Obstetrics & Gynecology and Reproductive Biology, 55-59.
  • Yi-Long Huang, Tsai-Wen Chung, Chia-Mao Chang, Chih-Hau Chen, Chen-Chung Liao, Yeou-Guang Tsay, Gwo-Chyuan Shaw, Shwu-Huey Liaw, Chung-Ming Sun* and Chao-Hsiung Lin* 2012, Aug. "Qualitative analysis of the fluorophosphonate-based chemical probes targeting recombinant and endogenous serine hydrolase" Analytical and Bioanalytical Chemistry, 2387-2396.
  • Yao-Ping Lin, Chih-Yu Yang, Chen-Chung Liao, Wen-Chung Yu, Chin-Wen Chi and Chao-Hsiung Lin* 2012, Jul. "Plasma protein characteristics of long-term hemodialysis survivors". PLoS One, 7, e40232.
  • Yi-Chang Liu, I-Hsuan Lin, Wei-Jen Chung, Wensi S. Hu, Wailap Victor Ng,Chi-Yu Lu, Tsung-Yen Huang, Hung-Wei Shu, Kwang-Jen Hsiao, Shih-Feng Tsai, Chuan-Hsiung Chang* and Chao-Hsiung Lin* 2012, Apr. "Proteomics characterization of cytoplasmic and lipid-associated membrane proteins of human pathogen Mycoplasma fermentans M64" PLoS One, e35304.
  • Yi-Feng Huang, Jing-Jer Lin, Chao-Hsiung Lin, Yeu Su* and Shih-Chieh Hung* 2012, May "c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP-2 via phosphorylation of Runx2 at Ser104" Journal of Bone and Mineral Research, 1093-1105.
  • Yi-Ying Chiou, Shu-Ling Fu, Wey-Jinq Lin, and Chao-Hsiung Lin* 2012, Feb. "Proteomics analysis of in vitro protein methylation during Src-induced transformation" Electrophoresis 451-461.