教師簡介

  • 兼任教授
  • 周成功
  • Chen-Kung Chou
  • 02-2826-7000 ext.6266
  • ckchou@ym.edu.tw
  • 圖資大樓9樓R901
  • 專業領域
  • 訊息傳導、腫瘤生物學
  • 研究方向
    • 以基因體學及蛋白體學的方法檢驗肝癌形成期間基因表現的變化以瞭解肝癌發生的生物學基礎。
    • 利用帶有B型肝炎病毒蛋白並因以誘發發炎反應之基因轉殖鼠作為研究模式,研究B型肝炎病毒與宿主先天免疫反應間複雜的交互作用並 據以瞭解此病毒與宿主的交互作用如何影響或導致肝癌。
    • 整合兩種老鼠模式(肝臟再生與B型肝炎病毒大表面抗原轉殖小鼠)的基因微陣列基因表現圖譜並具以發掘在此二模式中相似或相異且可 能具有調控功能的新基因,進一步在實驗室中研究該基因在人類肝癌發生的過程所扮演的角色。
    • 研發新的抗B型肝炎病毒藥物或有效的策略以遏阻或治療B型肝炎病毒相關之肝病如慢性肝炎、急性肝炎、肝硬化及肝癌等。
  • 教授科目
  • 巨人的肩膀:孟德爾之夢-101年的基因歷史-
    腦科學的跨文化研究
    生命科學(一上):生命科學總論
    生命科學(一下):生命科學總論
    生物學特論(一)
    生物學特論(二)
    現代生物學研究方法
  • 經歷
  • -present
    國立陽明大學
    生命科學系暨基因體科學研究所
    兼任教授
  • 長庚大學生物醫學系
    教授
  • 臺北榮總教學研究部
    特約研究員
  • 2001-2004
    國立陽明大學生命科學系
    教授
  • 1994-2004
    國立陽明大學
    微生物及免疫學研究所
    兼任教授
  • 1994-2004
    國立陽明大學
    生化暨分子生物研究所
    兼任教授
  • 1994-2004
    國立陽明大學遺傳學研究所
    兼任教授
  • 1988-1994
    國立陽明醫學院
    微生物及免疫學研究所
    兼任教授
  • 1988-1994
    國立陽明醫學院
    生化暨分子生物研究所
    兼任教授
  • 1988-1994
    國立陽明醫學院遺傳學研究所
    兼任教授
  • 學歷
  • 美國愛因斯坦醫學院
    分子生物學 博士

代表著作

  • Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK*, Chen CM. (2006) Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Exp Cell Res. 2006 Jan 18; in press[Epub ahead of print] [領域: Cell Biology, IF:4.007, 排名(Ranking):47/154], 通訊作者
  • Wu BK, Li CC, Chen HJ, Chang JL, Jeng KS, Chou CK, Hsu MT, Tsai TF. (2006) Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice. Biochem Biophys Res Commun. 2006 Feb 17;340(3):916-28. [領域: Biochemistry & Molecular Biology, IF:2.904, 排名(Ranking):103/261]
  • Li CC, Chou CK, Wang MH, Tsai TF. (2006) Overexpression of ABIN-2, a negative regulator of NF-kB, delays liver regeneration in the ABIN-2 transgenic mice. Biochem Biophys Res Commun. Mar 31;342(1):300-9. [領域: Biochemistry & Molecular Biology, IF:2.904, 排名(Ranking):103/261]
  • Yang CW, Hsiao CF, and Chou CK. (2005)Evaluation of Experimental Designs for Two-Color cDNA Microarrays. J. of Computational Biology. November 12(9):1202-20
  • Chang Y, Lee TC, Li JC, Lai TL, Chua HH, Chen CL, Doong SL, Chou CK, Sheen TS, Tsai CH. (2005) Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma. Head & Neck. October;27(10):873-82.
  • Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY. (2005) Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J Biol Chem. Mar 11;280(10):9013-22.
  • Yang CW, Su JY, Tsou AP, Chau GY, Liu HL, Chen CH, Chien CY, Chou CK*. (2005)Integrative genomics based identification of potential human hepatocarcinogenesis-associated cell cycle regulators: RHAMM as an example. Biochem Biophys Res Commun. May 6;330(2):489-97.
  • Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY. (2005)Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol Cell Biol. Jul;25(14):5789-800.
  • Li Y, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, Cheng YC. (2005)Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 16(3):193-201.
  • Wang JY, Chiu JH, Tsai TH, Tsou AP, Hu CP, Chi CW, Yeh SF, Lui WY, Wu CW, Chou CK. (2005) Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice. Int J Mol Med. Aug;16(2):221-31.
  • Tu LC, Chou CK, Chen CY, Chang YT, Shen YC, Yeh SF. (2004)Characterization of the cytotoxic mechanism of Mana-Hox, an analog of manzamine alkaloids. Biochim Biophys Acta. 1672:148-56.
  • Wang YH, Lee EJ, Wu CM, Luh TY, Chou CK, Lei HY. (2004)Inhibition of middle cerebral artery occlusion-induced focal cerebral ischemia by carboxyfullerene. J. Drug Del. Sci. Tech. 14:45-9.
  • Liu WK, Yen PF, Chien CY, Fann MJ, Su JY, Chou CK*. (2004) The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKγ to block activation of the transcription factor NF-κB and potentiate apoptosis. Biochem. J. 378:867-76
  • Lee CH, Ni YH, Chen CC, Chou CK, Chang FH. (2003) Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells. Biochim Biophys Acta. 1611:55-62.
  • Huang HL, Fang LW, Lu SP, Chou CK, Luh TY, Lai MZ. (2003) DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene. 22:8168-77.
  • Lin YL, Shiao MS, Mettling C, Chou CK. (2003) Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. Virology. 314:253-60.
  • Tsou AP, Chuang YC, Su JY, Yang CW, Liao YL, Liu WK, Chiu JH, Chou CK*. (2003) Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers. J Biomed Sci. 10:625-35. SCI, NHRI-EX91-9001BL, 89-B-FA22-2-4
  • Liu WK, Chien CY, Chou CK, Su JY.(2003) An LKB1-Interacting Protein Negatively Regulates TNFalpha-Induced NF-kappaB Activation. J Biomed Sci. 10: 242-52.
  • Chien CY, Liu WK, Chou CK, Su JY. (2003) The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. FEBS Lett. 543:55-60. SCI, NSC-90-2320-B-010-057, 89-B-FA22-2-4, NSC-90-2320-B-010-081, NHRI-EX90-9001BL
  • Tsou AP, Yang CW, Huang CY, Yu CT, Lee YC, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH, Chou CK*. (2003) Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene. 22: 298-307. SCI, NSC91-2323-B075-001.
  • Chiu AW, Huang YL, Huan SK, Wang YC, Ju JP, Chen MF, Chou CK. (2002) Potential molecular marker for detecting transitional cell carcinoma. Urology. 60:181-5.
  • Tsao N, Luh TY, Chou CK, Chang TY, Wu JJ, Liu CC, Lei HY.(2002) In vitro action of carboxyfullerene. J Antimicrob Chemother. 49:641-9.
  • Lin AM, Fang SF, Lin SZ, Chou CK, Luh TY, Ho LT. (2002) Local carboxyfullerene protects cortical infarction in rat brain. Neurosci Res. 43:317-21.
  • Tu LC, Chou CK, Chen HC, Yeh SF.(2001) Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells. J Biomed Sci. 8:184-90. SCI, NSC88-2315-B-010-002-MH
  • Tsao N, Luh TY, Chou CK, Wu JJ, Lin YS, Lei HY. (2001) Inhibition of group A streptococcus infection by carboxyfullerene. Antimicrob Agents Chemother. 45: 1788-93.
  • Liu MA, Huang AM, Chou CK, Liaw GJ, Wu CW.(2001) Utilization of Drosophila eye to probe the functions of two mammalian serine/threonine kinases, Snk and HsHPK. J Biomed Sci. 8:270-7.