教師簡介

  • 兼任副教授
  • 盧重光
  • Chung-Kuang Lu
  • 02-2820-1999 ext.5441
  • 個人網站
  • http://www.nricm.edu.tw/files/15-1000-382,c102-1.php
  • 專業領域
  • 天然物化學,有機光譜學,層析學,藻、菌類培養技術,微生物培養
  • 研究方向
  • 利用生物學與化學相結合的篩選方法,由海洋與陸地特殊棲所篩選共生於其他生物體中的微生物,發展藥用新資源,以現代層析技術配合活性篩選平台,從中發掘具有生物活性的新穎化合物,進一步以高靈敏高解析的NMR與質譜等技術完成化合物的結構解析,並與藥理學家合作,進行新先導藥物的研究開發。對具有重要生物活性的天然產物進行結構修飾,探討其結構與生物活性之關係。

    目前主要的研究主題包括:

    • 由神農本草上品藥物中找尋長壽、美容之秘密。
    • 調控海洋渦鞭毛藻Gambierdiscus spp.之生長條件,利用於量產Na+ channel activators。
    • 國際合作分離-100m水深之海洋微生物、純化並確認天然物之結構,使之成為具潛力之先導藥物。
    • 自特殊棲所之微生物中分離、純化並確認新穎結構之天然物,開發具生物活性之成分,使之成為具潛力之先導藥物。
    • 海洋單細胞藻Prorocentrum屬與藍綠菌Lyngbya屬之具生物活性物質研究。
    • 調控特殊棲所之微生物之生長條件,利用於量產特用化學成分。

  • 教授科目
  • 天然藥物化學
    專題討論(碩)
  • 經歷
  • 國立陽明大學
    生命科學系暨基因體科學研究所
    兼任副教授
  • 衛生福利部
    國家中醫藥研究所中藥化學研究組
    副研究員
  • 國立海洋生物博物館
    助理研究員
  • 國立東華大學海洋生物科技研究所
    助理教授
  • 臺北醫學大學藥學系
    助理教授
  • 學歷
  • 國立臺灣大學
    海洋研究所 博士

代表著作

NCBI PubMed: Chung-Kuang Lu (Please click!!)


  • Yu, C.-H., Lu, C.-K., Su, H.-M., Chiang, T.-Y., Hwang, C.-C., Liu, T., & Chen, Y.-M. (2015). Draft genome of Myxosarcina sp. strain GI1, a baeocytous cyanobacterium associated with the marine sponge Terpios hoshinota. Standards in Genomic Sciences, 10:28. doi:10.1186/s40793-015-0011-3
  • Shen, Y.-C., Lu, C.-K., Liou, K.-T., Hou, Y.-C., Lin, Y.-L., Wang, Y.-H., . . . Wang, H.-W. (2015). Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses. Journal of Ethnopharmacology. doi:10.1016/j.jep.2015.07.018.
  • Hou, Y.-C., Lu, C.-K., Wang, Y.-H., Chern, C.-M., Liou, K.-T., Wang, H.-W., & Shen, Y.-C. (2013). Unique mechanisms of sheng yu decoction (聖愈湯 Shèng Yù Tang) on ischemic stroke mice revealed by an integrated neurofunctional and transcriptome analysis. Journal of Traditional and Complementary Medicine, 3(4), 240-249. doi:10.4103/2225-4110.119703
  • More, S. V., Chang, T.-T., Chiao, Y.-P., Jao, S.-C., Lu, C.-K., & Li, W.-S. (2013). Glycosylation enhances the anti-migratory activities of isomalyngamide A analogs. European Journal of Medicinal Chemistry, 64, 169-178. doi:10.1016/j.ejmech.2013.03.044
  • Chen, H.-J., Shen, Y.-C., Lin, C.-Y., Tsai, K.-C., Lu, C.-K., Shen, C.-C., & Lin, Y.-L. (2012). Metabolomics study of Buyang Huanwu Tang Decoction in ischemic stroke mice by 1H NMR. Metabolomics, 8(5), 974-984. doi:10.1007/s11306-011-0394-0
  • Chen, T.-Y., Lin, H.-Y., Lin, C.-C., Lu, C.-K., & Chen, Y.-M. (2012). Picochlorum as an alternative to Nannochloropsis for grouper larval rearing. Aquaculture, 338-341, 82-88. doi:10.1016/j.aquaculture.2012.01.011
  • Chang, T. T., Shivaji, V. M., Lu, I. H., Hsu, J.-C., Chen, T.-J., Jen, Y. C., Lu, C. K., Li, W.-S. (2011). Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro. European Journal of Medicinal Chemistry, 46(9), 3810-3819. doi:10.1016/j.ejmech.2011.05.049
  • Lee, T.-H., Lu, C.-K., Wang, G.-J., Chang, Y.-C., Yang, W.-B., & Ju, Y.-M. (2011). Sesquiterpene glycosides from Cosmospora joca. Journal of Natural Products, 74(7), 1561-1567. doi:10.1021/np200056e
  • Lin, Y.-L., Lu, C.-K., Huang, Y.-J., & Chen, H.-J. (2011). Antioxidative caffeoylquinic acids and flavonoids from Hemerocallis fulva flowers. Journal of Agricultural and Food Chemistry, 59(16), 8789-8795. doi:10.1021/jf201166b
  • Lu, C.-K., Wang, S.-K., & Duh, C.-Y. (2011). New pregnane steroids from Formosan red alga Ceratodictyon spongiosum and symbiotic sponge Sigmadocia symbiotica. Bulletin of the Chemical Society of Japan, 84(9), 943-946. doi:10.1246/bcsj.20110100
  • Wang, H.-W., Liou, K.-T., Wang, Y.-H., Lu, C.-K., Lin, Y.-L., Lee, I. J., . . . Shen, Y.-C. (2011). Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. Journal of Ethnopharmacology, 138(1), 22-33. doi:10.1016/j.jep.2011.06.033
  • Chung-Kuang Lu*, Yi-Min Chen, Siang-Hang Wang, 2010, Prorocentin-4,a novel linear polyketide from a marine dinoflagellate Prorocentrum sp. Tetrahedron Letters 51, 6911-6914.
  • Huey-Lang Yang, Chung-Kuang Lu, Shu-Fen Chen, Young-Mao Chen, Yi-Min Chen*, 2010, Isolation and Characterization of Taiwanese Heterotrophic Microalgae: Screening of Strains for Docosahexaenoic Acid (DHA) Production. Marine Biotechnology 12, 173–185.
  • Huang, S.J., Kuo, C.M., Lin, Y.C., Chen, Y.M., and Lu, C.K.* (2009) Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae. Tetrahedron Lett., 50, 2512-2515.
  • Lu, C.K.*, Chen, Y.M., Wang, S.H., Wu, Y.Y., and Cheng, Y.M. (2009) Formosalides A and B, cytotoxic 17-membered ring macrolides from a marine dinofalgellate Prorocentrum sp. Tetrahedron Lett., 50,1825-1827.
  • Lee, T.H., Lu, C.K., Kuo, Y.H., Lo, J.M., and Lee, C.K.* (2008) Unexpected novel pheophytin peroxides from the leaves of Biden pilosa. Helv. Chim. Acta, 91, 79-84.
  • Chao, C.H., Huang, H.C., Wu, Y.C., Lu, C.K., Dai, C.F., and Sheu, J.H.* (2007) Glycolipids from the formosan soft coral Lobophytum crassum. Chem. Pharm. Bull., 55, 1720-1723.
  • Chen, S.P., Chao, C.H., Huang, H.C., Wu, Y.C., Lu, C.K., Dai, C.F., and Sheu, J.H.* (2006) New β-caryophyllene-derived terpenoids from the formosan soft coral Sinularia gibberosa. Bull. Chem. Soc. Jap.,79, 1547-1551.
  • Chao, C.H., Hsieh, C.H., Chen, S.P., Lu, C.K., Dai, C.F., and Sheu, J.H.* (2006) Sinularianins A and B, novel sesquiterpenoids from the formosan soft coral Sinularia sp. Tetrahedron Lett., 47, 5889-5891.
  • Chen, S.P., Ahmed, A.F., Dai, C.F., Lu, C.K., Hu, W.P., Wang, J.J., and Sheu, J.H.* (2006) Sinugiberosides A-E, new terpenoids with cyclic peroxyhemiketal from the soft coral Sinularia gibberosa. Tetrahedron, 62,6802-6807.
  • Chao, C.H., Hsieh, C.H., Chen, S.P., Lu, C.K., Dai, C.F., Wu, Y.C., and Sheu, J.H.* (2006) Novel cyclic sesquiterpene peroxides from the formosan soft coral Sinularia sp. Tetrahedron Lett., 47, 2175-2178.
  • Su, J.H., Tseng, Y.J., Huang, H.H., Ahmed, A.F., Lu, C.K., Wu, Y.C., and Sheu, J.H.* (2006) 9, 11-Secosterols from the soft corals Sinularia lochmodes and Sinularia leptoclados. J. Nat. Prod., 69,850-852.
  • Lu, C.K.*, Chou, H.N., Lee, C.K., and Lee, T.H. (2005) Prorocentin, a new polyketide from the marine dinoflagellate Prorocentrum lima. Org. Lett., 7, 3893-3896.