教師簡介

  • 專任教授
  • 陳俊銘
  • Chun-Ming Chen
  • 02-2826-7000 ext.7339/lab: ext.5721 or 5785
  • cmchen@ym.edu.tw
  • 傳統醫學大樓甲棟1樓R110
  • 專業領域
  • 發育生物學、癌症基因學
  • 實驗室簡介
  • • 以轉殖基因小鼠與人類癌症類器官培養模式探討上皮癌症的形成與惡化
    我們以轉殖基因小鼠為模式,利用特定組織專一性的基因剔除或表現系統,廣泛地在單層柱狀上皮細胞或是複層上皮的基底細胞,誘導多個抑癌基 因(如Pten,p53, DPH1/Ovca1等)缺失,同時誘導報導基因(如綠螢光蛋白基因)的表現,讓我們能夠在不同器官的柱狀上皮或基底上皮剔除抑癌基因時,進行研究並追蹤癌症細胞的起始與 進展的機制。此外,器官專一性的基因剔除系統也讓我們能更專一地探討特定的癌症成因。我們目前對於肝癌與攝護腺癌的疾病動物模式有成熟的 分析平台,而對於胰臟癌與卵巢癌的起源細胞及其惡化機制,亦正在積極探討中。另一方面,建立臨床癌症手術檢體的類器官培養,作為研究高度 複雜的上皮癌之活體外三維培養平台,藉以了解源自不同病人的癌症類器官之共通性與歧異性,希望在未來能藉此而發展更好的治療策略來對抗癌 症,並對癌症精準醫療提供新的想法。

    • 目前實驗室的研究方向與計畫分列如下:

  • • 研究方向與計畫 Current Research Projects
  • 1. 以轉殖基因小鼠模式分析卵巢上皮癌起始與進展的起源細胞 Characterization of the Cells of Origin for Ovarian Epithelial Cancer Initiation and Progression Using Transgenic Mouse Models (科技部計畫105-2320-B-010-028-MY3)

    2. 以轉殖基因小鼠與類器官培養技術探討DPH1在胰臟導管腺癌的起始與進程 Uncover the Roles of Diphthamide Biosynthesis Enzyme DPH1 in Pancreatic Ductal Adenocarcinoma Initiation and Progression Using Transgenic Mouse Models and Organoid Cultures (科技部計畫108-2320-B-010-018-MY3)

    3. 以肝臟代謝區塊的觀點解析肝癌的起源細胞 Decipher the Cells of Origin for Hepatocellular Carcinoma: Insights into the Metabolic Zonation (國家衛生研究院計畫 NHRI-EX108-10824BI)

  • 教授科目
  • 生命科學(二下)分子生物學
    癌症生物學
    小鼠遺傳﹑發育與表現型分析
    論文閱讀與分析方法(三)
    論文閱讀與分析方法(四)
    生命科學教學
  • 獲獎
  • 2005
    吳大猷先生紀念獎
  • 2003
    The Connie and Jim Walter Fellowship in Sarcoma
  • 2001
    M.D. Anderson Cancer Center, Prostate Cancer Research Program Award
  • 經歷
  • 2016-present
    國立陽明大學
    生命科學系暨基因體科學研究所
    教授
  • 2008-2016
    國立陽明大學
    生命科學系暨基因體科學研究所
    副教授
  • 2004-2008
    國立陽明大學
    生命科學系暨基因體科學研究所
    助理教授
  • 2000-2004
    Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA
    博士後研究員
  • 1998-2000
    國軍桃園總醫院病理部
    義務役少尉
  • 學歷
  • June 1998
    國立陽明大學
    生化所 博士
  • June 1993
    國立陽明大學
    生化所 碩士
  • June 1991
    中山醫學院
    營養系 學士

五年內代表著作

    * corresponding author

  • Chan, C-H, Chen, C-M., Wu Lee, Y-H, and You, L-R.* DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss. Mol Cancer Res, 2019; 17: 555-566.
  • Tu, W-L, You, L-R, Tsou, A-P, and Chen, C-M*. Pten haplo-deficiency accelerates liver tumor growth in microRNA122a-null mice via expansion of periportal hepatocyte-like cells. Am J Pathol 2018; 188: 2688-2702.
  • Hsu W-H, Chen C-M, You L-R*. COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring. Sci Rep. 2017, 7: 12386.
  • Wang C-Y, Tang M-C, Chang W-C, Furushima K, Jang C-W, Behringer RR, Chen C-M*. PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility. Biol Reprod. 2016; 95: 51, 1-9.
  • Li H-K, Mai R-T, Huang H-D, Chou C-H, Chang Y-A, Chang Y-W, You L-R, Chen C-M, Wu Lee Y-H*. DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. Sci Rep. 2016;6:28637.
  • Chen C-Y, Chan C-H, Chen C-M, Tsai Y-S, Tsai T-Y, Wu Lee Y-H, You L-R*. Targeted Inactivation of Murine Ddx3x: Essential Roles of Ddx3x in Placentation and Embryogenesis. Hum Mol Genet. 2016; 25: 2905-2922.
  • Lu T-L and Chen C-M*. ß-Catenin in epithelial tumorigenesis. Aging 2015; 7: 467-468.
  • Liang C-C, Lu T-L, Yu Y-R, You L-R and Chen C-M*. ß-Catenin activation drives thymoma initiation and progression in mice. Oncotarget 2015; 6:13978-13993.
  • Lu T-L and Chen C-M* .Differential Requirements for ß-Catenin in Murine Prostate Cancer Originating from Basal versus Luminal Cells. J Pathol. 2015; 236: 290-301.
  • Yu Y-R, You L-R, Yan Y-T and Chen C-M*. Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker Syndrome. Hum Mol Genet, 2014; 23:5579-5596.
  • Liang C-C, You L-R, Yen J-J, Liao N-S, Yang-Yen H-F, Chen C-M*. Thymic epithelial beta-catenin is required for adult thymic homeostasis and function. Immunol Cell Biol 2013; 91: 511-23.
  • Lu T-L, Huang Y-F, You L-R, Chao N-C, Su F-Y, Chang J-L and Chen C-M*. Conditionally Ablated Pten in Prostate Basal Cells Promotes Basal-to-Luminal Differentiation and Causes Invasive Prostate Cancer in Mice. Am J Pathol 2013; 182: 975-991.
  • Cheng T-L, Wu Y-T, Lai C-H, Kao Y-C, Kuo C-H, Liu S-L , Hsu Y-Y, Chen P-K, Cho C-F, Wang K-C, Lin W-L, Chang B-I, Chen C-M, Weiler H, Shi GY, Wu HL* Thrombomodulin Regulates Keratinocyte Differentiation and Promotes Wound Healing. J Invest Dermatol 2013; 133:1638-1645.
  • Hsu W-H, Yu Y-R, Hsu S-H, Yu W-C, Chu Y-H, Chen,Y-J, Chen C-M and You L-R* The Wilms’ tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium. Exp Cell Res 2013; 319: 1365-1381.
  • Chiang M-F, Yang S-Y, Lin I-Y, Hong J-B, Lin S-J, Ying H-Y, Chen C-M, Wu S-Y, Liu F-T, Lin K-I*. Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice. Proc Natl Acad Sci USA 2013; 110: 6476-6481.