• 專任教授
  • 陳俊銘
  • Chun-Ming Chen
  • 02-2826-7000 ext.7339/lab: ext.5721 or 5785
  • 傳統醫學大樓甲棟1樓R110
  • 專業領域
  • 發育生物學、癌症基因學
  • 實驗室簡介
  • 1. 以轉殖基因小鼠模式探討上皮癌症的形成

    2. 以轉殖基因大小鼠模式探討器官的發育與恆定

  • 研究方向
  • The primary interests of my laboratory are to explore the molecular and cellular mechanisms that control the development of embryonic tissues/organs, the homeostasis of adult epithelial tissues, and initiation and progression of cancer. We are particularly interested in the roles of tumor suppressors p53, OVCA1 (Ovarian Cancer Gene 1), PTEN (phosphatase and tensin homolog deleted on chromosome 10) and APC (Adenomatous polyposis coli) in different cancers. To address the roles of these tumor suppressors, we create and develop different mouse genetic resources exhibiting inducible Cre recombinase in different epithelial lineages. Using genetic, biochemical and pharmacological dissection based on our established mouse models, the downstream signaling circuits that act as the key mediators during cancer progression are currently being characterized. Our research outcomes may help us to identify genes or therapeutic targets that block the carcinogenic process.

    In addition, we have focused on the development of the forebrain, the heart, the thymus and the reproductive tracts in the mouse. Using different genetic modified mice, the abnormal phenotypes occurred in the mutant mice are often to be the entry points for us to explore potential mechanisms resulting in developmental defects during mammalian organogenesis.

    Historically, in addition to mice, rats have been used extensively as experimental animals for biomedical research. However, compared to the very large number of genetically modified mice, there are very few mutant rats due to technology limitations. Currently, my laboratory collaborates with Dr. Richard Behringer at the M.D. Anderson Cancer Center who has established a piggyBac-mediated gene-trap mutagenesis system to create a large collection of mutant rats (Furushima et al., 2012, Genetics). The primary goal of this collaborative project is to accelerate and extend the generation of mutant rats, which may enable us to discover novel biological function of the mutated genes and to develop potential disease models in rats.

  • 教授科目
  • 生命科學(二下)分子生物學
  • 獲獎
  • 2005
  • 2003
    The Connie and Jim Walter Fellowship in Sarcoma
  • 2001
    M.D. Anderson Cancer Center, Prostate Cancer Research Program Award
  • 經歷
  • 2016-present
  • 2008-2016
  • 2004-2008
  • 2000-2004
    Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA
  • 1998-2000
  • 學歷
  • June 1998
    生化所 博士
  • June 1993
    生化所 碩士
  • June 1991
    營養系 學士


    * corresponding author

  • Hsu W-H, Chen C-M, You L-R*. COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring. Sci Rep. 2017 (accepted).
  • Wang C-Y, Tang M-C, Chang W-C, Furushima K, Jang C-W, Behringer RR, Chen C-M*. PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility. Biol Reprod. 2016; 95: 51, 1-9.
  • Li H-K, Mai R-T, Huang H-D, Chou C-H, Chang Y-A, Chang Y-W, You L-R, Chen C-M, Wu Lee Y-H*. DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. Sci Rep. 2016;6:28637.
  • Chen C-Y, Chan C-H, Chen C-M, Tsai Y-S, Tsai T-Y, Wu Lee Y-H, You L-R*. Targeted Inactivation of Murine Ddx3x: Essential Roles of Ddx3x in Placentation and Embryogenesis. Hum Mol Genet. 2016; 25: 2905-2922.
  • Lu T-L and Chen C-M*. ß-Catenin in epithelial tumorigenesis. Aging 2015; 7: 467-468.
  • Liang C-C, Lu T-L, Yu Y-R, You L-R and Chen C-M*. ß-Catenin activation drives thymoma initiation and progression in mice. Oncotarget 2015; 6:13978-13993.
  • Lu T-L and Chen C-M* .Differential Requirements for ß-Catenin in Murine Prostate Cancer Originating from Basal versus Luminal Cells. J Pathol. 2015; 236: 290-301.
  • Yu Y-R, You L-R, Yan Y-T and Chen C-M*. Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker Syndrome. Hum Mol Genet, 2014; 23:5579-5596.
  • Liang C-C, You L-R, Yen J-J, Liao N-S, Yang-Yen H-F, Chen C-M*. Thymic epithelial beta-catenin is required for adult thymic homeostasis and function. Immunol Cell Biol 2013; 91: 511-23.
  • Lu T-L, Huang Y-F, You L-R, Chao N-C, Su F-Y, Chang J-L and Chen C-M*. Conditionally Ablated Pten in Prostate Basal Cells Promotes Basal-to-Luminal Differentiation and Causes Invasive Prostate Cancer in Mice. Am J Pathol 2013; 182: 975-991.
  • Cheng T-L, Wu Y-T, Lai C-H, Kao Y-C, Kuo C-H, Liu S-L , Hsu Y-Y, Chen P-K, Cho C-F, Wang K-C, Lin W-L, Chang B-I, Chen C-M, Weiler H, Shi GY, Wu HL* Thrombomodulin Regulates Keratinocyte Differentiation and Promotes Wound Healing. J Invest Dermatol 2013; 133:1638-1645.
  • Hsu W-H, Yu Y-R, Hsu S-H, Yu W-C, Chu Y-H, Chen,Y-J, Chen C-M and You L-R* The Wilms’ tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium. Exp Cell Res 2013; 319: 1365-1381.
  • Chiang M-F, Yang S-Y, Lin I-Y, Hong J-B, Lin S-J, Ying H-Y, Chen C-M, Wu S-Y, Liu F-T, Lin K-I*. Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice. Proc Natl Acad Sci USA 2013; 110: 6476-6481.