教師簡介

  • 合聘教授
  • 林達顯
  • Ta-Hsien Lin
  • 02-2871-2121 ext. 2703 or 2671
  • 榮總致德樓BF12-4
  • 榮總核磁共振研究室網頁
  • https://wd.vghtpe.gov.tw/mre/Fpage.action?muid=3048&fid=2129
  • 專業領域
  • 結構生物學、超導核磁共振學
  • 研究方向
    • 利用高解相異核多維核磁共振技術決定生物巨分子之三維結構,並探討分子結構與功能之關聯,俾以進行疾病導向及分子病理層次之研究。
    • 「動脈粥狀硬化」和「失智症」等老年退化性疾病相關的生物巨分子,如Apolipoprotein E 和 β-amyloid peptide 之結構生物學研究。
    • 探討蛋白磷酸酶(protein phosphatase 1; PP1)與其蛋白抑制劑(protein inhibitor),例如Inhibitor-1、Inhibitor-2及DARPP-32等之交互作用機制,期能以分子結構之觀點一窺蛋白質磷酸化及活化機轉之堂奧於一二。
    • 結構生物學及以結構為基礎的藥物設計。
  • 教授科目
  • 結構生物學(二)
    生物物理化學(一)
    專題討論(碩)
  • 經歷
  • 2016-present
    臺北榮民總醫院醫學研究部
    兼任研究員
  • 2007-present
    國立陽明大學醫學系生化科
    專任教授
  • 2007-present
    國立陽明大學
    生化暨分子生物研究所
    合聘教授
  • 2007-present
    國立陽明大學
    生命科學系暨基因體科學研究所
    合聘教授
  • 2007-present
    國立陽明大學生物醫學資訊研究所
    合聘教授
  • 2013-2016
    臺北榮民總醫院醫學研究部
    兼任副研究員
  • 2006-2013
    臺北榮民總醫院教學研究部
    兼任副研究員
  • 2000-2007
    國立陽明大學醫學系生化科
    專任副教授
  • 1998-2000
    國立陽明大學
    生化暨分子生物研究所
    兼任副教授
  • 1996-2000
    臺北榮民總醫院教學研究部
    副研究員
  • 1993-1996
    中央研究生物醫學科學研究所
    博士後研究員
  • 學歷
  • 1993
    美國加州大學聖地牙哥分校
    化學 博士
  • 1984
    國立臺灣師範大學
    化學系 理學士

代表著作

    期刊發表

  • Chun-Tien Kuo, Yi-Lin Chen, Wei-Tse Hsu, Su-Chun How, Yu-Hong Cheng, Shu-Shun Hsueh, Hwai-Shen Liu, Ta-Hsien Lin, Josephine W. Wu*, Steven S.-S. Wang* " Investigating the effects of erythrosine B on amyloid fibril formationderived from lysozyme", 2017, International Journal of Biological Macromolecules, 98, 159-168.
  • Chu-Ting Liang, Hsien-Bin Huang, Chih-Ching Wang, Yi-Ru Chen, Chi-Fon Chang, Ming-Shi Shiao, Yi-Cheng Chen*, Ta-Hsien Lin* "L17A/F19A Substitutions Augment the α-Helicity of β-Amyloid Peptide Discordant Segment", PLoS ONE, 11, e0154327.
  • Chi-Jen Lo, Chih-Ching Wang, Hsien-bin Huang, Chi-Fon Chang, Ming-Shi Shiao, Yi-Cheng Chen* and Ta-Hsien Lin* "Arctic mutation accelerates Aβ aggregation in SDS through reducing the helical propensity of residues 15-25", 2015, Amyloid, 22, 8-18.
  • Chi-Jen Lo, Chia-Lin Chyan, Yi-Chen Chen, Chi-Fon Chang, Hsien-bin Huang* and Ta-Hsien Lin*, "Resonance assignments and secondary structure of apolipoprotein E C-terminal domain in DHPC micelles", 2015, Biomol. NMR Assign., 9, 187-190.
  • Chih-Kai Chang, Wei-An Chen, Chao-Yu Sie, Shen-Chieh Lin, Lilian Tsai-Wei Lin, Ta-Hsien Lin, Cheng-Che Hsu*, Steven S.-S. Wang* "Investigating the effects of plasma pretreatment on the formation of ordered aggregates of lysozyme", 2015, Colloids and Surfaces B: Biointerfaces, 126, 154–161.
  • Deli Irene, Fu-Hsing Sung, Jian-Wen Huang, Ta-Hsien Lin, Yi-chen Chen and Chia-Lin Chyan* "Resonance assignments and secondary structure of calmodulin in complex with its target sequence in rat olfactory cyclic nucleotide-gated ion channel", 2014, Biomol. NMR Assign., 8, 97-102.
  • Shu-Hsiang Huang, Shyue-Chu Ke, Ta-Hsien Lin, Hsin-Bin Huang, Yi-Cheng Chen* "Effect of C-Terminal Residues of Aβ on Copper Binding Affinity, Structural Conversion and Aggregation", 2014, PLOS ONE, 9, e90385.
  • Yu-Shan Lin, Hsien-Lu Huang, Weiting Liu, Ta-Hsien Lin*, and Hsien-bin Huang* "Identification of the high molecular weight isoform of phostensin", 2014, Int. J. Mol. Sci., 15, 1068-1079.
  • Chen-Yuan Kao, Jun-Kun Lai, Ta-Hsien Lin, Yu-Jiun Lin, Jeng-Shiung Jan∗, Steven S.-S. Wang∗ "Examining the inhibitory actions of copolypeptides against amyloidfibrillogenesis of bovine insulin", 2013, Biochemical Engineering Journal, 78, 181-188.
  • Yi-Ru Chen, Hsien-bin Huang, Chi-Jen Lo, Chih-Ching Wang, Li-Kang Ho, Hsin-Tzu Liu, Ming-Shi Shiao, Ta-Hsien Lin*, Yi-Cheng Chen* "Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Aβ40", 2013, PLOS ONE, 8, e61847.
  • Deli Irene, Jian-Wen Huang, Tse-Yu Chung, Feng-Yin Li, Jason T.-C. Tzen, Ta-Hsien Lin and Chia-Lin Chyan* "Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel", 2013, J. Biomol. Struct. Dyn., 34, 414-425.
  • Tzu-Fan Wang, Ning-Sheng Lai, Kuang-Yung Huang, Hsien-Lu Huang, Ming-Chi Lu, Yu-Shan Lin, Chun-Yu Chen, Su-Qin Liu, Ta-Hsien Lin* and Hsien-Bin Huang* "Identification and Characterization of the Actin-Binding Motif of Phostensin", 2012, Int. J. Mol. Sci., 13, 15967-15982.
  • Chih-Ching Wang, Hsien-bin Huang, Huey-Jen Tsay, Ming-Shi Shiao, Wen-Jin Winston Wu, Yi-Chen Chen* and Ta-Hsien Lin* "Characterization of Aβ aggregation mechanism probing by Congo red", 2012, J. Biomol. Struct. Dyn., 30, 160-169.
  • Yi-Ru Chen, Hsien-bin Huang, Chi-Jen Lo, Chih-Ching Wang, Chia-Li Su, Hsin-Tzu Liu, Ming-Shi Shiao, Ta-Hsien Lin* and Yi-Chen Chen* "Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40", 2011, Biochem. Biophy. Res. Commun., 405, 91-95.
  • H. Chou, M.F. Tam, S.-S. Lee, R.-B. Tang, T.-H. Lin, H.-Y. Tai, Y.-S. Chen, H.-D. Shen* "Asp159 is a critical core amino acid of an IgE-binding and cross-reactive epitope of a dust mite allergen Der f 7", 2011, Molecular Immunology, 48, 2130-2134.