教師簡介

  • 專任助理教授
  • 可文亞
  • Wen-Ya Ko
  • 02-2826-7000 ext.7979／lab: 6082 or 6069
  • wenko@ym.edu.tw
  • 圖書資訊暨研究大樓6樓R629
  • 專業領域
  • 族群遺傳學、族群基因體學、演化學
  • 研究方向

  • Research in our laboratory mainly focuses on identifying evolutionary forces that underlie patterns of genetic variation in humans and other organisms of interest. We are broadly interested in studying a variety of topics including identifying recent evolutionary adaptation in diverse human ethnic groups, admixed ancestry characterization of human genomes, genome evolution, and conservation genetics. Current research projects include:

    • Admixed ancestry characterization of human genomes
    • Identifying genetic signatures of recent adaptation in humans
    • Computational modelling of evolutionary processes using coalescence theory
    • Conservation genetics of endangered Taiwanese fruit bats (Pteropus dasymallus formosus)
  • 教授科目
  • 遺傳學概論
    分子族群遺傳學與基因體資料分析
    生命科學技術
    生物統計學
    專題討論（碩）
    生態與演化
    生命科學教學
  • 獲獎
  • 2013-2015
    Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship for Foreign Researchers
  • Nov. 2-6 2010
    Trainee Research Semifinalist Award for the 60th annual meeting of the American Society of Human Genetics (ASHG)
  • Jul. 4-8 2010
    Postdoctoral Research Travel Award for the Society of Molecular Biology and Evolution (SMBE)
  • Mar. 22-25 2010
    Burroughs Wellcome Travel Scholarship for Ecology and Evolution of Infectious Diseases (EEID) Meeting
  • 2006
    Biology Graduate Student Research Excellence Awards
  • 經歷
  • Aug, 2015-present
    國立陽明大學
    生命科學系暨基因體科學研究所
    助理教授
  • 學歷
  • 2007
    美國賓州州立大學
    生物學　博士

代表著作

    期刊發表

  • Higasa, K., Miyake, N., Yoshimura, J., Okamura, K., Niihori, T., Saitsu, H., et al., 2016. Human genetic variation database, a reference database of genetic variations in the Japanese population. Journal of Human Genetics.
  • Ranciaro A., Campbell M. C., Hirbo J. B., Ko, W.-Y., et al., 2014. Genetic Origins of Lactase Persistence and the Spread of Pastoralism in Africa. Am J Hum Genet 94: 496-510.
  • Ko, W.-Y., P. Rajan, F. Gomez, et al., 2013 Darwinian selection acting on different human APOL1 variants among diverse African populations. Am J Hum Genet 93: 90-102.
  • Gomez F., Tomas G., Ko, W.-Y. et al. Patterns of Nucleotide and Haplotype Diversity at ICAM-1 Across Global Human Populations with Varying Levels of Malaria Exposure. Human Genetics 132: 987-999.
  • Ko, W.-Y., K. Kaercher, E. Giombini et al., 2011 Effects of gene conversion and natural selection on the evolution of human glycophorins coding for MNS polymorphism in malaria endemic African populations. Am J Hum Genet 88: 741-754 (selected as a featured article).
  • Iida, K., D. L. Cox-Foster, X. Yang, W.-Y. Ko, D. R. Cavener, 2007 Expansion and evolution of insect GMC oxidoreductases. BMC Evolutionary Biology 7:75.
  • Ko, W.-Y., S. Piao, and H. Akashi., 2006 Strong regional heterogeneity in base composition evolution on the Drosophila X chromosome. Genetics 174:349-362.
  • Akashi, H., W.-Y. Ko, S. Piao, A. John, P. Goel, C. F. Lin, and A. Vitins, 2006 Molecular evolution in the Drosophila melanogaster species subgroup: Frequent parameter fluctuations on the time-scale of molecular divergence. Genetics 172: 1711-1726.
  • Ko, W.-Y., R. David, and H. Akashi, 2003 Molecular phylogeny of the Drosophila melanogaster species subgroup. J. Mol. Evol. 57: 562-573.
  • Tishkoff, S. A., M. Campbell, and J. Hirbo, J. Jarvis, W.-Y. Ko et al., 2010 Genomic variation and adaptation in Africa: Implications for human evolutionary history and disease. Genome Biology 11 (Suppl 1): 120.

    專書發表

  • Ko, W.-Y., Gomez, F., and S. A. Tishkoff., 2012 Evolution of human erythrocyte-specific genes involved in malaria susceptibility, a chapter in "Evolution In The Fast Lane: Rapidly Evolving Genes and Genetic Systems. Singh R. S., Xu J. and Kulathinal R. J. Ed. Oxford University Press, Oxford.
  • Gomez, F., W.-Y. Ko, A. Davis, and S. A. Tishkoff. Impact of Natural Selection due to Malarial Disease on Human Genetic Variation. In J.F. Brinkworth and K. Pechenkina (eds) "Primates, Pathogens and Evolution. Developments in Primatology: Progress and Prospects" 38:117-160 Springer publishing, New York.

    研討會發表

  • Wen-Ya Ko, Koichiro Higasa, Maiko Narahara, Kaori Iida, Fumihiko Matsuda, and Ryo Yamada, Genetic origins and admixed ancestry characterization of Japanese people. The annual meeting of the American Society of Human Genetics (ASHG), Baltimore, Maryland, Oct 6 - 10, 2015
  • Ko, W.-Y., P. Rajan, F. Gomez, et al., 2013 Darwinian selection acting on different human APOL1 variants among diverse African populations. Congress of the European Society for Evolution Biology (ESEB), Lisbon, Portugal, Aug 19-24 2013
    *Platform presentation
  • Ko, W.-Y., F. Gomez, and S. A. Tishkoff, Spatially heterogeneous selection on human ApoL1 variants among diverse African populations in trypanosomiasis endemic areas. The annual meeting of the Society for Molecular Biology and Evolution (SMBE), Kyoto, Japan, July 26-30 2011
    *Platform presentation
  • Ko, W.-Y., K. Kaercher, and S. A. Tishkoff, Adaptive evolution of human glycophorin loci in malaria endemic African populations. The 60th annual meeting of the American Society of Human Genetics (ASHG), Washington DC, Nov 2 - 6, 2010
    *Platform presentation with trainee research award
    *Invitation for a press briefing session at the meeting on the latest advances in evolutionary and population genetics research.
  • Ko, W.-Y., K. Kaercher, and S. A. Tishkoff, Adaptive evolution of human glycophorin loci in malaria endemic African populations. The annual meeting of the Society for Molecular Biology and Evolution (SMBE), Lyon, France, July 4 - 8 2010
    *Platform presentation with travel award
  • Ko, W.-Y., F. Gomez, and S. A. Tishkoff, An evolutionary and population genetic approach to malaria susceptibility in Africa. The 79th annual meeting of the American Association of Physical Anthropologists (AAPA), Albuquerque, New Mexico, Apr 14 - 17 2010
    *Invited talk
  • Ko, W.-Y., K. Kaercher, and S. A. Tishkoff, Population genetic analysis of erythrocyte surface glycoproteins in malaria-endemic human populations of Africa.
    Poster presentations at:
    ‧ 58th Annual meeting of the American Society of Human Genetics, Philadelphia, Pennsylvania, Nov 11 - 15, 2008
    ‧ Poster presentation at Ecology and Evolution of Infectious Disease PI Meeting, Albuquerque, New Mexico, Dec 02 - 05 2007
  • Ko, W.-Y., S. Piao, and H. Akashi, Strong regional heterogeneity in base composition evolution on the Drosophila X chromosome.
    Poster presentations at:
    ‧ Evolution 2006, the join annual meeting of the Society for the Study of Evolution (SSE), the Society of Systematic Biologists (SSB), and the American Society of Naturalists (ASN) at Stony Brook University, Stony Brook, NY, June 23 - 27 2006
    ‧ Genomes, Evolution, and Bioinformatics, the annual meeting for the Society for Molecular Biology and Evolution at Arizona State University, Tempe, AZ, May 24 - 28 2006
    ‧ 47th Annual Drosophila Research Conference, Houston, TX, March 29 - April 2 2006
    ‧ The Comparative and Functional Genomics of Summer Symposium at Pennsylvania State University, University Park, PA, July 20 - 23 2005
    Oral presentations at:
    ‧ Northeast Ecology and Evolution Conference (NEEC) at Pennsylvania State University, University Park, PA, March 18 - 20 2005
  • Ko, W.-Y., R. David, J. Anoop, C.-F. Lin, S. Piao, and H. Akashi, Lineage-specific molecular evolution in the Drosophila melanogaster species subgroup. Poster presentation at Genome and Evolution conference for the Society for Molecular Biology and Evolution (SMBE) at Pennsylvania State University, University Park, PA, June 17 - 20 2004
  • Ko, W.-Y., R. David, and H. Akashi, Molecular phylogeny of the Drosophila melanogaster species subgroup.
    Poster presentations at:
    ‧ Eastern Great Lake Molecular Evolution Meeting (EGLME VIII) at Cornell University, Ithaca, NY, April 24 2004
    ‧ The annual conference for the Society of Molecular Biology and Evolution (SMBE), Newport Beach, CA, June 26 - 29 2003

    邀請演講

  • Ko, W.-Y. and S. A. Tishkoff, Effects of gene conversion and natural selection on the evolution of human glycophorins coding for MNS polymorphism in malaria endemic African populations. Young Researchers Conference On Evolutionary Genomics, Tokyo, Japan, August 1-2 2011
  • Ko, W.-Y., P. Rajan, F. Gomez, et al., 2013 Darwinian selection acting on different human APOL1 variants among diverse African populations. International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB), Taichug, Taiwan, Nov 8-9 2013

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