教師簡介

  • 合聘教授
  • 孫以瀚
  • Y. Henry Sun
  • 02-2788-3605
  • 中研院跨領域大樓8樓8B02
  • 個人網站
  • http://www.imb.sinica.edu.tw/~mbyhsun/index.html
  • 專業領域
  • Molecular Mechanisms Regulating Drosophila Visual System Development
  • 研究方向
  • 我們的研究興趣在果蠅視覺系統的發育的分子調控機制。目前主要有三個研究方向:(1) 如何決定細胞發育為眼睛,(2) 感光神經細胞與膠細胞在發育過程中的交互作用,(3) 生長中的複眼如何吸引氣管伸入。

    The Drosophila eye and antenna arise from a single epithelium disc called the eye-antennal imaginal disc. Genes specifying the eye fate and antenna fate have been identified. We are studying the mechanism for subdividing this disc into distinct eye and antennal field, the interaction between the two parts, and the establishment and maintenance of their boundary.

    We are also studying the interaction between the eye and the brain, specifically the interaction between the photoreceptor neurons and glia cells from the brain, including glia in the optic lobe of the brain and the retinal basal glia (RBGs) that migrate from the brain into the eye disc. We are studying the mechanisms regulating the proliferation, survival, migration and distribution of the glia within the visual system, and also their effects on photoreceptor development and functions. We also found that the adult photoreceptors send a survival signal to the optic lamina in the brain to maintain the survival of glia in its target field.

    As the eye grows larger, the need for oxygen increases. We found that trachea extends into the growing eye during the pupal stage. The retinal cells secret a FGF ligand to induce the ingrowth of trachea. We are investigating the molecular mechanism regulating this process, and its relationship to hypoxia.

  • 教授科目
  • 進階發育生物學
  • 經歷
  • 2006-present
    中央研究院分子生物研究所
    特聘研究員
  • Jul, 1999-2006
    中央研究院分子生物研究所
    研究員
  • Feb, 1988-Jun, 1999
    中央研究院分子生物研究所
    副研究員
  • 1986-1988
    美國耶魯大學生物系
    博士後研究員
  • 學歷
  • 1986
    美國加州理工學院
    生物組 博士
  • 1978
    國立臺灣大學
    植物學系 學士

代表著作

  • Huang, Y. S., Ku, H. Y., Tsai, Y. C., Chang, C. H., Pao, S. H., Sun, Y. H.* and Chiou, A. (2017) 5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila. SCIENTIFIC REPORTS. doi:10.1038/srep44945, 2017-03.
  • Tsao, C. K., Ku, H. Y., Lee, Y. M., Huang, Y. F. and Sun, Y. H.*. (2016) Long Term Ex Vivo Culture and Live Imaging of Drosophila Larval Imaginal Discs. PLoS One. 11(9), e0163744, 2016-09
  • Lee, Y.-M. and Sun, Y. H.*. (2015) Drosophila as a model to study role of glia in neurodegeneration. Journal of Neurogenetics. 29(2-3), 69-79, 2015-08.
  • Lee, Y.-M. and Sun, Y. H.*. (2015) Maintenance of Glia in the Optic Lamina Is Mediated by EGFR Signaling byPhotoreceptors in Adult Drosophila. PLoS Genetics. 11(4), e1005187, 2015-04.
  • Tsai, Y.-C., Grimm, S., Chao, J.-L., Yao, C.-K., Hofmeyer, K., Shen, J., Eichinger, F., Michalopoulou, T., Wang, S.-C., Sun, Y. H.* and Pflugfelder, G. O.* (2015) Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling. PLoS One. 10(3), e0120236, 2015-03.
  • Chang, Y.-H. and Sun, Y. H.*.(2014) Carrier of Wingless (Cow), a Secreted HSPG, Promotes Extracellular Transport of Wingless. PLoS One. 9(10), e111573, 2014-10.
  • Chu, W. C., Lee, Y. M. and Sun Y. H.*. (2013) FGF /FGFR Signal Induces Trachea Extension in the Drosophila Visual System. PLoS One. 8(8), e73878, 2013-08.
  • Chang, Y-H., Li, W-R. and Sun, Y. H. (2012) Functional screening of human genes by expression in Drosophila identifies Enthoprotin/LqfR as a regulator of hematopoiesis. Zoological Studies. 51(7), 1122-1138, 2012.
  • Wang, C.-W. and Sun, Y. H.* (2012) Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila. Development. 139(18), 3413-3421, 2012.
  • Wang, L.-H., Huang, Y.-T., Tsai, Y.-C., and Sun, Y. H. (2010) The role of eyg Pax gene in the development of the head vertex in Drosophila. Dev Biol. 337(2), 246-258, 2010-01.
  • H. A. Duong, C. W. Wang, R. Nagaraj, Y. H. Sun and A. J. Courey. (2008) Non-Cell-Autonomous Inhibition of Photoreceptor Development by Dip3. Dev Biol. 323, 105-13, 2008-11.
  • L.-H. Wang, S.-J. Chiu and Y. H. Sun. (2008) Temporal switching of regulation and function of eyg gone (eyg) in Drosophila eye development. Dev Biol. 321, 515-527, 2008.
  • Yao, J.-G. #, Weasner, B. M. #, Wang, L.-H., Jang, C.-C., Weasner, B., Tang, C.-Y., Salzer, C. L., Chen, C.-H., Hay, B, Sun, Y. H.* and Kumar, J. P.* (2008) Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila. Dev. Biol. 315:535-531. (# equal contribution; * equal contribution, both corresponding author)
  • Duong, H.A.#, Wang, C.W.#, Sun, Y. H. , and Courey, A.J.* (2008) Transformation of eye to antenna by misexpression of a single gene. Mech. Dev. 125, 130-141. (*equal contribution, both corresponding author)
  • Tsai, Y.-C., Yao, J.-G., Chen, P.-H, Posakony, J.W., Barolo, S., Kim, J., and Sun, Y. H. (2007) Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development. Dev. Biol. 306, 760-771.
  • Yao, J.-G. and Sun, Y. H. (2005) Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development. EMBO J. 24, 2602-2612.
  • Chao, J.-L., Tsai, Y.-C., Chiu, S.-J., and Sun, Y. H. (2004) Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye. Development 131, 3839-3847.
  • Tsai, L. and Sun, Y. H. (2004) Long-range effect by Upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development. Genesis 39, 141-153.
  • Jang, C.-C., Jones, N., Chao, J.-L., Bessarab, D. A., Kuo, Y., Jun, S., Desplan, C., Beckendorf, S., and Sun, Y. H. (2003) Two Pax genes, eye gone and eyeless, act in parallel in determining Drosophila eye development. Development 130, 2939-2951.
  • Kango-Singh, M., Singh, A. and Sun, Y. H. (2003) Eyeless collaborates with Hedgehog and Decapentaplegic signaling in Drosophila eye induction. Develop. Biol. 256, 49-61.
  • Tang, C.-Y. and Sun, Y. H. (2002) Use of mini-White as a reporter gene to screen for GAL4 insertions with spatially restricted expression pattern in the developing eye in Drosophila. Genesis 34, 39-45.
  • Singh, A., Kango-Singh, M. and Sun, Y. H. (2002) Eye suppression, a novel function of teashirt, requires WINGLESS signaling. Development 129, 4271-4280.
  • Jaw, T. J., Knoepfler, P. S., Yao, L.-C., Pai, C.-Y., Tang, C.-Y., Chang, L.-P., Berthelsen, J., Blasi, F., Kamps, M. P., and Sun, Y. H. (2000) Direct interaction of two homeoproteins, Homothorax and Extradenticle, is essential for EXD nuclear localization and function. Mech. Dev. 91, 279-291.
  • Yao, L.-C., Liaw, G.-J., Pai, C.-Y., and Sun, Y. H. (1999) A common mechanism for antenna-to-leg transformation in Drosophila: Suppression of hth transcription by four HOM-C genes. Dev. Biol. 211, 268-276.
  • Pai, C.-Y., Kou, T.-S., Jaw, T. J., Kurant, E., Chen, C.-T., Bessarab, D.A., Salzberg, A., and Sun, Y. H. (1998) The Homothorax homeoprotein activates nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila. Genes & Devel. 12, 435-446.